Abstrac

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  • Publicado : 28 de octubre de 2010
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abstraAbstract (Summary)
OBJECTIVE: Relapsing to overeating is a stubborn problem in obesity treatment. We tested the hypothesis that context cues surrounding palatable food (PF) intake have thepower to disrupt caloric regulation even of less PF. Context cues are non-food cues that are in the environment where PF is habitually eaten. DESIGN: Rats were conditioned to associate intake ofOreo cookies as the PF to cages with distinct context cues that differed from cues in cages where they were only given chow. PF naturally stimulated greater caloric intake. The rats were then testedin the PF cage with only chow available to determine whether the PF-paired cues, alone, could elicit overeating of plain chow. SUBJECTS: Non-food-deprived female Sprague-Dawley rats. MEASUREMENTS:Intake of plain chow under PF-paired cues vs chow-paired cues was compared. This was also measured in tests that included a morsel of PF as a priming stimulus. We also controlled for any effect ofbinge-prone vs binge-resistant status to predict cued-overeating. RESULTS: Rats consumed significantly more chow when exposed to context cues paired earlier with PF than with chow (P<0.01). Thiseffect occurred using various cues (for example, different types of bedding or wallpaper). The effect was strengthened by priming with a morsel of PF (P<0.001) and was unaffected by baselinedifferences in propensity to binge on PF. CONCLUSION: Context-cues associated with PF intake can drive overeating even of a less PF and abolish the ability of rats to compensate for the calories of aPF primer. Just as drug-associated context cues can reinstate drug-addiction relapse, PF-paired cues may trigger overeating relapses linked to weight regain and obesity. This model should helpidentify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity.
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