Apoptosis, or programmed cell death, is a normal component of the development and health of multicellular organisms. Cells die in response to a variety of stimuli and during apoptosis theydo so in a controlled, regulated fashion. This makes apoptosis distinct from another form of cell death called necrosis in which uncontrolled cell death leads to lysis of cells, inflammatoryresponses and, potentially, to serious health problems. Apoptosis, by contrast, is a process in which cells play an active role in their own death (which is why apoptosis is often referred to as cellsuicide).
Apoptosis or also caled Cell Death, is a process in which a cell is degraded in order for it to be ultimately engulfed and recycled. It can occur when a cell has become mutated and is on theverge of becoming a cancer.
Apoptosis is also the reason why we don't have webbed hands and feet.
What basically happens is that the killer t cell communicates with the diseased cell by adhering toit by binding its death ligand to the death receptor on the diseased cell. This causes adapter proteins to attach to the cytosolic side of the receptor. This leads to a signal cascade which involvesthe recruitment of various other proteins and ultimately results in the death of the cell.
Necrosis is a form of traumatic cell death that results from acute cellular injury. Apoptosis in contrast tonecrosis, confers advantages during an organism's life cycle. For instance during the development of the fetus in the mother, the differentiation of fingers and toes occurs because cells between thefingers apoptose with the end result that the digits are separate. Approximately between 50 billion and 70 billion cells die each day due to apoptosis in the average human adult. In a year, thisamounts to the proliferation and subsequent destruction of a mass of cells equal to an individual's body weight.
Unregulated apoptosis could exacerbate or cause disease such as:
* AIDS, in which T...