Asma

Magnesium sulfate for treating exacerbations of acute asthma in the emergency department (Review)
Rowe BH, Bretzlaff J, Bourdon C, Bota G, Blitz S, Camargo CA

This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2009, Issue 3 http://www.thecochranelibrary.com

Magnesium sulfate for treating exacerbations of acuteasthma in the emergency department (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

TABLE OF CONTENTS HEADER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . OBJECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CHARACTERISTICS OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DATA AND ANALYSES . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . Analysis 1.1. Comparison 1 Intravenous MgSO4 vs placebo, Outcome 1 Admission to hospital. . . . . . . . Analysis 1.2. Comparison 1 Intravenous MgSO4 vs placebo, Outcome 2 Pulmonary function testing. . . . . . Analysis 1.3. Comparison 1 Intravenous MgSO4 vs placebo, Outcome 3 Vital signs. . . . . . . . . . . . Analysis 1.4. Comparison 1 Intravenous MgSO4vs placebo, Outcome 4 Major Side Effects. . . . . . . . . . Analysis 1.5. Comparison 1 Intravenous MgSO4 vs placebo, Outcome 5 ED Treatment Time. . . . . . . . . Analysis 2.1. Comparison 2 Intravenous MgSO4 vs Placebo (Severe Asthma subgroup), Outcome 1 Pulmonary function testing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . WHAT’S NEW . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . HISTORY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CONTRIBUTIONS OF AUTHORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DECLARATIONS OF INTEREST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SOURCES OF SUPPORT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . INDEX TERMS . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 2 2 2 3 4 6 7 8 8 10 18 19 20 21 22 22 23 23 24 24 24 24 25

Magnesium sulfate for treating exacerbations of acute asthma in the emergency department (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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[Intervention Review]

Magnesium sulfate for treating exacerbations of acuteasthma in the emergency department
Brian H Rowe1 , Jennifer Bretzlaff2 , Christopher Bourdon2 , Gary Bota2 , Sandra Blitz3 , Carlos A Camargo4 of Emergency Medicine, University of Alberta, Edmonton, Canada. 2 St Joseph’s Site, Sudbury Regional Hospital, Sudbury, Canada. 3 Division of Emergency Medicine, University of Alberta, Edmonton AB, Canada. 4 EMNet Coordinating Center, Massachusetts GeneralHospital, Boston, Massachusetts, USA Contact address: Brian H Rowe, Department of Emergency Medicine, University of Alberta, Room 1G1.43 Walter C. Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, Alberta, T6G 2B7, Canada. brian.rowe@ualberta.ca. Editorial group: Cochrane Airways Group. Publication status and date: Edited (no change to conclusions), published in Issue 3, 2009. Review...