Celiac disease (CD) is a systemic disorder, autoimmune nature, which has the special to be the only well-defined and clarified origin. Is due to the existence of a permanentintolerance to gluten, which occurs in genetically predisposed individuals and affects primarily, though not exclusively, the digestive tract. Its morphological substrate is defined by the presence of achronic inflammatory process affecting the mucosa and sub mucosa of the small intestine and characterized from Clinically, the presence of various manifestations systemic. Can occur at any age in life,both during childhood and adolescence and is very common also appeared in adulthood. Its frequency is quite high in patients of the third age and it is estimated that about 20% of patients have morethan 60 years at diagnosis.
The pediatrician Samuel Gee gave the first modern day description of the condition in children in a lecture at Hospital for Sick Children, London 1887. More than 2 millionpeople in the United States have the disease, or about 1 in 133 people.
The causative agent is the gluten, which is a set of proteins present only in a group of grain, mainly wheat, but rye, barleyand oats, but not in corn or rice. Gluten may also be found in everyday products such as medicines, vitamins, and lip balms.
When people with celiac disease eats foods or use products containinggluten, their immune system responds by damaging or destroying villi (the tiny, fingerlike protrusions lining the small intestine). Villi normally allow nutrient from food to be absorbed through the wallsof the small intestine into the bloodstream.
Signs and symptoms
The most common symptoms are abdominal cramping usually accompanied of fluctuating swelling, dyspepsia or indigestion, Symptomsof gastro-esophageal reflux, such as heartburn and regurgitation and altered bowel habit ranging from diarrhea to constipation, or alternating of both. Along with them is often presented symptoms of...
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