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  • Páginas : 14 (3270 palabras )
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  • Publicado : 6 de diciembre de 2011
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Nombre/ Función |
AmphiregulinBifunctional growth-modulating glycoprotein Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells. |
Bone morphogenetic protein 2 (BMP2)Induces cartilage and bone formation. |
Bone Morphogenetic Protein 4 (BMP4)Induces cartilage and bone formation. Also act in mesoderminduction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction |
Eosinophil Chemotactic Factor (ECF)In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.Binds to CCR3. |
Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1)Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.  |
FMS LikeTyrosine Kinase 3 Ligand (Flt3L)Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. |
Chemokine C-X3-C-Motif Ligand 1 (CX3CL1)The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelialcells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. |
Neutrophil Activating Protein 3 (NAP3)Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-foldhigher chemotactic activity.  |
Monocyte Chemotactic Protein 1 (MCP1)Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytesinto the arterial wall during the disease process of atherosclerosis. |
Monocyte Chemotactic Protein 2 (MCP2)Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effectmost predominantly of CCL7, and also of CCL2 and CCL5 and CCL8 |
Monocyte Chemotactic Protein 3 (MCP3)Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. |
Macrophage Derived Chemokine (MDC)May play a role in the trafficking ofactivated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes.Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. |
Macrophage Inflammatory Protein 1 Alpha (MIP1a)Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian...
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