Vitamin D Deficiency in Children and Adolescents with Type 1 Diabetes
Ajda Mutlu1, Gül YeşiltepeMutlu2, Elif Özsu2, Filiz Mine Çizmecioğlu2, Şükrü Hatun2
2Kocaeli 1Kocaeli University, Medical Faculty, Department of Pediatrics, Kocaeli, Turkey University, Medical Faculty, Department of Pediatrics,Division of Pediatric Endocrinology and Diabetes, Kocaeli, Turkey
There is a growing interest in the non-skeletal effects of vitamin D in recent years (1). There are some reportssuggesting that vitamin D deficiency has a negative effect on insulin sensitivity and that it increases type 2 diabetes prevalence in adults (2,3,4,5). Some studies establishing a relationship betweenvitamin D and insulin sensitivity in children have also been published (6,7). Recently, high rates of vitamin D deficiency have been reported in children with type 1 diabetes (T1D) and it is emphasized thatthis situation may have a negative effect on bone health (8,9,10,11,12,13). A positive effect of vitamin D administered in high doses (4000 IU/day) on metabolic control has also been reported (14).However, prevalence of vitamin D deficiency in children with T1D and its effects on metabolic control, insulin requirement and lipid levels have not yet been fully clarified. In this study, we aimed toinvestigate the frequency and effects of vitamin D deficiency in children with T1D. A high rate of vitamin D deficiency is encountered among adolescents in our region (15).
ABSTRACT Objective: Toinvestigate the frequency and effects of vitamin D deficiency in children with type 1 diabetes (T1D) in a region which is known to have a high rate of vitamin D deficiency among adolescents. Methods:In this prospective cross-sectional study, 120 children and adolescents with T1D (55 girls and 65 boys) aged 3-20 years were evaluated. Serum 25-hydroxyvitamin D [25(OH)D], parathormone (PTH), and...