Diabetes

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Schizophr Res. Author manuscript; available in PMC 2009 April 6.
Published in final edited form as: Schizophr Res. 2008 August ; 103(1-3):110–113. doi:10.1016/j.schres.2008.04.017.

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Glucose abnormalities in the siblings of people withschizophrenia
Emilio Fernandez-Egeaa, Miguel Bernardoa,b, Eduard Parelladaa, Azucena Justiciaa, Clemente Garcia-Rizoa, Enric Esmatjesb,c, Ignacio Congetb,c, and Brian Kirkpatrickd,* aHospital Clinic Schizophrenia Program, Department of Psychiatry, Neuroscience Institute, Hospital Clinic, Barcelona, Spain
b

Institute of Biomedical Research Agusti Pi iSunyer (IDIBAPS), Barcelona, Spain

c Endocrinology and Diabetes Section, Institute of Digestive and Metabolic Diseases, Hospital Clinic,

Spain
d

Department of Psychiatry andHealth Behavior, Medical College of Georgia, 997 St. Sebastian Way, Augusta, Georgia 30912, USA

Abstract
Background: Some studies suggest that schizophrenia may be associatedwith an increased risk of diabetes, independently of antipsychotic medications and other confounding factors. Previous studies have also suggested that there is an increasedprevalence of diabetes in the relatives of schizophrenia probands. Method: First-degree siblings of schizophrenia probands (N = 6) and control subjects (N = 12) were administered a glucosetolerance test. Subjects were matched for gender, age, body mass index, neighborhood of residence, socio-economic status and smoking habits. Results: The siblings of schizophreniaprobands had a significantly increased two-hour mean glucose concentration compared to the control subjects (respective means [SD] were 100.5 mg/dL [27.7] vs. 78.0 [12.3]; p
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