Determined to succeed inacting, Pompeo moved to Los Angeles in 2001. She participed in the movie Mambo Café with Thalía. A turning point came when she was selected by director Brad Silberling in 2002 for a role in hisfilm Moonlight Mile playing Jake Gyllenhaal's sympathetic love interest. She also appeared in the film Daredevil playing Matt Murdock's (Ben Affleck) secretary Karen Page, but most of her scenes weredeleted from the theatrical version of the film. In 2002, Pompeo appeared in Catch Me If You Can and in 2003, Old School. Television guest roles include two episodes of Law & Order andan episode of Friends. She portrayed Jim Carrey's ex-girlfriend, Naomi, in the 2004 film Eternal Sunshine of the Spotless Mind. Although her scenes were cut from the film, she felt grateful thatdirector Michel Gondry chose her to appear in his film.
Pompeo landed her first major role in the ABC medical drama Grey's Anatomy, which is now in its eighth season, as the title character, MeredithGrey, a surgical resident at a prestigious hospital. In 2007, Pompeo was nominated for a Golden Globe for Best Actress in a Drama Series. That year, she also signed a new contractfor Grey's Anatomy that increased her salary to US$200,000 per episode. She is contracted with the show for eight seasons which is the standard length in Hollywood after which actors often demand largeraises.
On October 13, 2007, Pompeo was honored by the National Italian American Foundation for her achievement in entertainment at a black-tie gala in Washington, D.C.
On October 27, 2011Deadline.com reported that Ellen Pompeo has launched her own production company called Calamity Jane which sold its first project to ABC, an untitled show about female agents on the Secretary of State's...