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Online Submissions: wjg.wjgnet.com wjg@wjgnet.com doi:10.3748/wjg.15.4290

World J Gastroenterol 2009 September 14; 15(34): 4290-4297 World Journal of Gastroenterology ISSN 1007-9327
© 2009 The WJG Press and Baishideng. All rights reserved.

BRIEF ARTICLES

Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?

Katsuhiro Mabe, Mikako Takahashi, HaruhumiOizumi, Hideaki Tsukuma, Akiko Shibata, Kazutoshi Fukase, Toru Matsuda, Hiroaki Takeda, Sumio Kawata Katsuhiro Mabe, Division of Gastroenterology, KKR Sapporo Medical Center, Sapporo City 062-0931, Hokkaido, Japan Mikako Takahashi, Internal Medicine, Tsuruoka Kyoritsu Hospital, Tsuruoka City 997-0816, Yamagata, Japan Haruhumi Oizumi, Internal Medicine, Oizumi Medical Clinic, Yamagata City 990-0832,Yamagata, Japan Hideaki Tsukuma, Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City 537-8511, Osaka, Japan Akiko Shibata, Yamagata Prefectural Medical Center for Cancer and Lifestyle-Related Disease, Yamagata City 990-2292, Yamagata, Japan Kazutoshi Fukase, Internal Medicine, Yamagata Prefectural Central Hospital, Yamagata City990-2292, Yamagata, Japan Toru Matsuda, Yamagata Prefectural Shonai Public Health Center, Mikawa Town 997-1392, Yamagata, Japan Hiroaki Takeda, Sumio Kawata, Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata City 990-9585, Yamagata, Japan Author contributions: Mabe K, Oizumi H, Matsuda T, and Tsukuma H designed the research; Mabe K, Takahashi M, Oizumi H, Fukase K,Matsuda T, and Takeda H performed the research; Shibata A and Tsukuma H analyzed the data; Mabe K wrote the paper; Kawata S reviewed the paper. Correspondence to: Dr. Katsuhiro Mabe, MD, Division of Gastroenterology, KKR Sapporo Medical Center, Sapporo City 062-0931, Hokkaido, Japan. kmabe@kkr-smc.com Telephone: +81-11-8221811 Fax: +81-11-8329859 Received: June 29, 2009 Revised: July 29, 2009Accepted: August 5, 2009 Published online: September 14, 2009

RESULTS: A total of 4133 patients aged between 13 and 91 years (mean 52.9 years) were registered, and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 years. The sex- and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group, was 0.58 (95% CI: 0.28-1.19)and ratios by follow-up period (< 1 year, 1-3 years, > 3 years) were 1.16 (0.27-5.00), 0.50 (0.17-1.49), and 0.34 (0.09-1.28), respectively. Longer follow-up tended to be associated with better prevention of gastric cancer, although not to a significant extent. No significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy (32/2451patients, 1.31%) and those with treatment failure (11/639 patients, 1.72%). Among patients with duodenal ulcer, which is known to be more prevalent in younger individuals, the incidence of gastric cancer was significantly less in those with successful eradication therapy (2/845 patients, 0.24%) than in those with treatment failure (3/216 patients, 1.39%). CONCLUSION: H pylori eradication therapy forpeptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer.
© 2009 The WJG Press and Baishideng. All rights reserved.

Key words: Helicobacter pylori ; Peptic ulcer; Gastric cancer; Eradication therapy; Cancer prevention Peer reviewers: Dusan M Jovanovic, Professor, Institute of
Oncology, Institutski Put 4, Sremska Kamenica21204, Serbia; Yoshio Yamaoka, MD, PhD, Associate Professor, Department of Medicine/Gastroenterology, Baylor College of Medicine and VA Medical Center (111D), 2002 Holcombe Blvd, Houston, Texas 77030, United States Mabe K, Takahashi M, Oizumi H, Tsukuma H, Shibata A, Fukase K, Matsuda T, Takeda H, Kawata S. Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer? World...
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