Despite research dead ends, the horror of watching their son's health decline, and being surrounded by skeptics (including the coordinators of the supportgroup they attended), they persisted until they finally hit upon a therapy involving adding a certain kind of oil (actually containing two specific long chain fatty acids, isolated from rapeseed[canola] oil and olive oil) to their son's diet. They contacted over 100 firms around the world until they found an elderly British chemist (Don Suddaby) working for Croda International whowas willing to take on the challenge of distilling the proper formula. It proved successful in normalizing the accumulation of the very long chain fatty acids in the brain that had been causingtheir son's steady decline, thereby halting the progression of the disease. There was still a great deal of neurological damage remaining which could not be reversed until new treatments werefound to regenerate the myelin sheath (a lipid insulator) around the nerves.
The film ends with Lorenzo at the age of 14 showing definite improvement (he could swallow for himself and answeryes or no questions by blinking) but indicating more medical research is still needed. The end credits of the film note that Lorenzo also regained his sight and was learning to use a computer.