Abstract: The purpose of this article is to assess the long-term fertility and attitudes towards fecundity in men after radical inguinal orchiectomy and radiation therapy (RT) for Seminoma, and also to assess how often sperm cryopreservation is being offered to patients with Seminoma prior to treatment. A retrospective review wasconducted at 3 institutions (Wilford Hall Air Medical Center, Brooke Army Medical Center, and Fitzsimmons Army Medical Center) to identify patients who had undergone treatment of stage 1 or 2A Seminoma during the period from 1975 to 1997. Seventy-three or 212 (34%) patients meeting the selection criteria of stage 1 o 2A Seminoma provided information for this analysis. This was thought to be o goodresponse rate, given that many of the patients had changed duty stations or had separated from the military by the time this study started. We performed review of RT and tumor board records of 73 patients who were treated for testicular Seminoma at selected treatment facilities from 1975 to 1997. Patients completed questionnaires and phone interviews that focused on prior fertility, the desire tofather (more) children, other fertility-affecting factors (Varicocele, cryptorchidism, infection, and erectile dysfunction), and incidence of physician counseling with regard to cryopreservation. All patients were asked to obtain a current semen analysis (SA). Eleven (15%) patients reported that they tried to father children since completion of their RT. Seven of 11 (64%) successfully achievedpregnancy within a mean time of 3.5 years since RT (range: 1 month to 5 years). Of the 4 couples that were not successful, 1 had severe female factor infertility problems and a second had erectile dysfunction. A third had a past surgical history remarkable for vasectomy with subsequent vasectomy reversal. Nine patients provided SA. Mean sperm count and motility were 24.2 Mil/mL (range: 5-81 Mil/mL) and63.1% (range: 30-90%), respectively (normal SA values: count = 20 -250 Mil/mL, motility ›50%, and volume = 1.5-5.0 mL). No patients were azoospermic. Overall mean time interval from radiation therapy was 7.9 years. Radiation dose and time since RT did not correlate with either SA results or conception. Only 16 of 73 (22%) men had been offered pretreatment sperm cryopreservation by their counselingphysician. It is concluded that (1) patients who are greater than a 50% chance of regaining normal semen parameters, and all regain at least some spermatogenesis; (2) recovery of spermatogenesis is not related to therapeutic radiation dose with the use of modern shielding and RT portals; (3) the majority of treated patients who desire children can conceive; and (4) sperm cryopreservation remainsan underutilized option for Seminoma patients.
Key Words: Seminoma, radiotherapy, fertility, spermatogenesis.
(Am J Clin Oncol 2004;27: 584-588)
La fertilidad en los hombres después del tratamiento para la etapa 1 y 2A Seminoma
Resumen: El propósito de este artículo es evaluar la fertilidad a largo plazo y las actitudes hacia la fecundidad en los hombres después de la orquiectomía inguinalradical y la radioterapia (RT) de seminoma, y también para evaluar la frecuencia con la criopreservación de esperma se está ofreciendo a los pacientes con seminoma antes al tratamiento. Un estudio retrospectivo se realizó en tres instituciones (Wilford Hall Medical Center de aire, Brooke Army Medical Center, y Fitzsimmons Centro Médico del Ejército) para identificar a los pacientes que habíansido sometidos a tratamiento de estadio 1 o 2A Seminoma durante el período comprendido entre 1975 y 1997. Setenta y tres pacientes en 212 (34%) que cumplan los criterios de selección de la etapa 1 o 2A Seminoma proporcionaron información para este análisis. Este fue pensado para ser la tasa o buena respuesta, dado que muchos de los pacientes había cambiado los lugares de destino o se había separado...