Risk of High-Grade Cervical Intraepithelial Neoplasia among Young Women with Abnormal Screening Cytology
Stewart L. Massad, MD,1 Stephen Markwell,2Helen E. Cejtin, MD,3 and Yvonne Collins, MD4
Department of Obstetrics and Gynecology and 2Division of Statistics and Research Consulting, the SouthernIllinois University School of Medicine, Springfield; 3Department of Obstetrics and Gynecology, John Stroger Hospital, Chicago, IL; and 4Department ofObstetrics and Gynecology University of Illinois, Chicago, IL

j Abstract Objective. To estimate the risk of high-grade cervical disease among teenage womenwith abnormal cytology. Methods. Retrospective analysis of a prospectively collected database of females undergoing colposcopy for abnormal screeningcytology in an urban dysplasia clinic. Results. Among 211 eligible teens, high-grade squamous intraepithelial lesions were found in 17 (8%) on referralcytology and 4 (2%) on repeat cytology. High-grade cervical intraepithelial neoplasia was found in colposcopic biopsy specimens 30 (15%) of young women; nopatient had cancer. Age, referral Pap, ethnicity, parity, HIV serostatus, history of other sexually transmitted infections, smoking, oral contraceptive usecondom use, use of medroxyprogesterone, age at first intercourse, and the number of years since first intercourse did not predict increasing risk ofhigh-grade cervical intraepithelial neoplasia (CIN). In logistic regression, both number of partners $ 5 (p = 0.003) and a finding of any squamous intraepithelial [continua]

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