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James G. Tidball
J Appl Physiol 98:1900-1908, 2005. doi:10.1152/japplphysiol.01178.2004
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J Appl Physiol 98: 1900 –1908, 2005;
doi:10.1152/japplphysiol.01178.2004.

Invited Review

Biomechanics and Mechanotransduction in Cells and Tissues

HIGHLIGHTED TOPIC

Mechanical signal transduction in skeletal muscle growth and adaptation
James G. Tidball
Departments of Physiological Science, and Pathology and Laboratory
Medicine, Universityof California, Los Angeles, California

Downloaded from jap.physiology.org on November 20, 2008

Tidball, James G. Mechanical signal transduction in skeletal muscle growth
and adaptation. J Appl Physiol 98: 1900 –1908, 2005; doi:10.1152/japplphysiol.
01178.2004.—The adaptability of skeletal muscle to changes in the mechanical
environment has been well characterized at the tissue and systemlevels, but the
mechanisms through which mechanical signals are transduced to chemical
signals that influence muscle growth and metabolism remain largely unidentified. However, several findings have suggested that mechanical signal transduction in muscle may occur through signaling pathways that are shared with
insulin-like growth factor (IGF)-I. The involvement of IGF-I-mediated signaling for...