Aspirina Mas Heparina En Aborto Recurrente

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original article

Aspirin plus Heparin or Aspirin Alone in Women with Recurrent Miscarriage
Stef P. Kaandorp, M.D., MariëtteGoddijn, M.D., Ph.D., Joris A.M. van der Post, M.D., Ph.D., Barbara A. Hutten, Ph.D., Harold R. Verhoeve, M.D., Karly Hamulyák, M.D., Ph.D., Ben Willem Mol, M.D., Ph.D., Nienke Folkeringa, M.D., Ph.D.,Marleen Nahuis, M.D., Dimitri N.M. Papatsonis, M.D., Ph.D., Harry R. Büller, M.D., Ph.D., Fulco van der Veen, M.D., Ph.D., and Saskia Middeldorp, M.D., Ph.D.

A bs t r ac t
Background
From theDepartment of Obstetrics and Gynecology (S.P.K., J.A.M.P.), the Center for Reproductive Medicine (M.G., F.V.), the Department of Clinical Epidemiology, Biostatistics, and Bioinformatics (B.A.H.), and theDepartment of Vascular Medicine (H.R.B.), Academic Medical Center, University of Amsterdam, Amsterdam; Onze Lieve Vrouwe Gasthuis, Amsterdam (H.R.V.); University Hospital Maastricht, MaastrichtUniversity, Maastricht (K.H.); Máxima Medical Center, Veldhoven (B.W.M.); University Medical Center Groningen, University of Groningen, Groningen (N.F.); Medisch Spectrum Twente Hospital Group, Enschede(M.N.); Amphia Hospital, Breda (D.N.M.P.); and Leiden University Medical Center, University of Leiden, Leiden (S.M.) — all in the Netherlands. Address reprint requests to Dr. Goddijn at the Center forReproductive Medicine, H4205, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, the Netherlands, or at m.goddijn@amc.uva.nl. This article (10.1056/NEJMoa1000641) waspublished on March 24, 2010 at NEJM.org. N Engl J Med 2010;362:1586-96.
Copyright © 2010 Massachusetts Medical Society.

Aspirin and low-molecular-weight heparin are prescribed for women withunexplained recurrent miscarriage, with the goal of improving the rate of live births, but limited data from randomized, controlled trials are available to support the use of these drugs.
Methods

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