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Colombia Médica

Vol. 43 Nº 1, 2012 (Enero-Marzo)

Salivary cortisol levels as a predictor of preeclampsia in adolescents
Niveles de cortisol salivario como predictor de
preeclampsia enadolescentes
Jaime Salvador-Moysén, MD1, José M. Ramírez-Aranda, MD2,
Yolanda Martínez-López, ScD1, Marisela Aguilar-Durán, MSc1

Summary
Objective: To determine the usefulness of salivary cortisol as apredictor of preeclampsia in adolescents.
Methods: We carried out a nested case-control study. Somatometric, clinical, and biochemical data were obtained

from 100 healthy pregnant adolescents andsalivary cortisol was measured at 8:00, 12:00, and 20:00 hours on two
occasions during pregnancy, before 20 weeks, and after 30 weeks of gestation. The cortisol values between the group
of healthypregnant women and the group that developed preeclampsia were compared by using the Student’s t, MannWhitney, and Wilcoxon tests. Also, the ROC curve of cortisol values and the Positive and NegativePredictive values
of cortisol were estimated.
Results: Values >14.9 nmol/L of cortisol were observed in the group that developed preeclampsia, providing a
positive predictive value of 1 (100%).Values 14.9 nmol/L con un valor predictivo
de 1 (100%) en relación con la ocurrencia de preeclampsia; el grupo que fue seleccionado como control tuvo valores
1
2

Professor researcher, ScientificResearch Institute, Universidad Juárez del Estado de Durango, Durango, México. e-mail: jsmoysen@gmail.com
ymtzlopez@gmail.com aguilarduran_marisela@hotmail.com
Professor researcher, Department ofFamily Medicine, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de
Nuevo León, Monterrey, México. e-mail: rmz544383@yahoo.com.mx
Received for publication January 26, 2011Accepted for publication July 15, 2011

©
462012 Universidad del Valle, Facultad de Salud

Colomb Med. 2012; 43: 46-53

Colombia Médica
de cortisol 90 mm Hg, and proteinuria >300
mg/urine of...