Bioactive Compounds

Bioactive Compounds from Natural Sources

Bioactive Compounds from Natural Sources
Isolation, characterisation and biological properties

Edited by

Corrado Tringali
Università di Catania, Italy

LONDON AND NEW YORK

First published 2001 by Taylor & Francis 11 New Fetter Lane, London EC4P 4EE Simultaneously published in the USA and Canada by Taylor & Francis Inc, 29 West 35thStreet, New York, NY 10001 Taylor & Francis is an imprint of the Taylor & Francis Group This edition published in the Taylor & Francis e-Library, 2004. © 2001 Corrado Tringali All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in anyinformation storage or retrieval system, without permission in writing from the publishers. Every effort has been made to ensure that the advice and information in this book is true and accurate at the time of going to press. However, neither the publisher nor the authors can accept any legal responsibility or liability for any errors or omissions that may be made. In the case of drugadministration, any medical procedure or the use of technical equipment mentioned within this book, you are strongly advised to consult the manufacturer’s guidelines. British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Cataloging in Publication Data Bioactive compounds from natural sources : isolation, characterisation, andbiological properties / edited by Corrado Tringali, p. cm. “Simultaneously published in the USA and Canada.” Includes bibliographical references and index. ISBN 0–7484–0890–8 (alk. paper) 1. Pharmacognosy. 2. Natural products. I. Tringali, Corrado, 1950– RS160 .B55 2000 615'.19—do21 00–033765 ISBN 0-203-21231-2 Master e-book ISBN

ISBN 0-203-26972-1 (Adobe eReader Format) ISBN 0-7484-0890-8(Print Edition)

To Graziella and Paolo

Contents
PREFACE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix CHAPTER 1 Biological Screening Methods in the Search for Pharmacologically Active Natural Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 A.J.Vlietinck and S. Apers CHAPTER 2 Applications of Liquid Chromatography/UV/MS and Liquid Chromatography/NMR for the On-line Identification of Plant Metabolites . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 K. Hostettmann and J.-L. Wolfender CHAPTER 3 Applications of Modern NMR Techniques in the Structural Elucidation of Bioactive NaturalProducts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 P. Neri and C. Tringali CHAPTER 4 Bioactive Secondary Metabolites from Selected Mexican Medicinal Plants: Recent Progress . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129 R. Mata, J.-F. Rivero-Cruz and D. Chávez CHAPTER 5 Flavonoids as CancerChemopreventive Agents . . . . . . . . . . . . . . . . . . . . . . . . . 159 L.C. Chang and A.D. Kinghorn CHAPTER 6 Antitumor Drugs from the Secondary Metabolites of Higher Plants . . . . . . . . . . 189 Y.-H. Kuo and M.-L. King CHAPTER 7 Bioactive Taxoid Production from Natural Sources . . . . . . . . . . . . . . . . . . . . . . 283 M. Jaziri and M. Vanhaelen

I vii

BIOACTIVE COMPOUNDS FROMNATURAL SOURCES

CHAPTER 8 Anti-HIV Aromatic Compounds from Higher Plants . . . . . . . . . . . . . . . . . . . . . 305 F. De Simone, R. Aquino, N. De Tommasi, N. Mahmood, S. Piacente and C. Pizza CHAPTER 9 Antioxidative Plant Constituents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 H. Haraguchi CHAPTER 10 Antimalarial Natural Products . . . . . . . . . . . . . . . ....