Brucelosis

Brucellosis in humans and animals

Food and Agriculture Organization of the United Nations

World Organisation for Animal Health

WHO/CDS/EPR/2006.7

i

Brucellosis in humans and animals

Food and Agriculture Organization of the United Nations

World Organisation for Animal Health

Brucellosis in humans and animals

ii

WHO Library Cataloguing-in-Publication Data Brucellosisin humans and animals. Produced by the World Health Organization in collaboration with the Food and Agriculture Organization of the United Nations and World Organisation for Animal Health Principal author: M.J. Corbel. 1.Brucellosis - prevention and control. 2.Brucellosis - epidemiology. 3.Brucellosis - complications. 4.Guidelines. I.Corbel, M.J. II.World Health Organization. III.Food andAgriculture Organization of the United Nations. IV.World Organisation for Animal Health. ISBN 92 4 154713 8 ISBN 978 92 4 154713 0 (NLM classification: WC 310)

© World Health Organization 2006 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 7914857; e-mail: bookorders@who.int). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: permissions@who.int). The designations employed and the presentation of the material in this publication do not imply the expression of any opinionwhatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that theyare endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the publishedmaterial is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. The named authors alone are responsible for the views expressed in this publication.

iii

Contents
Principal author, list ofcontributors .......................................................................................................... vii Preface ............................................................................................................................................................................... viii Acknowledgments............................................................................................................................................................................... viii Abbreviations .................................................................................................................................................................................. ix

1. INTRODUCTION................................................................................................................................................................................... 1

2. CLINICAL MANIFESTATION .................................................................................................................... 3 2.1 The disease in humans ...................................................................................................... 4 2.1.1...