Ciencia

Asignación #1:
1- EU846981
2- Nombre de secuencia- HIV-1 clone C16 from Belgium envelope glycoprotein (env) gene, partial cds.

3- Taxonomia- Human immunodeficiency virus 1
4- Función de la secuencia- genomic DNA

5- Existen referencias- si

Abstract
* A cluster of four patients acutely infected with a genetically almost identical virus, allowed us to investigategenetic variability and disease progression in early HIV-1 infection with minimal interference of virus specific factors. Two of the patients were heterozygous for the 32-bp deletion in the CCR5 coreceptor gene. Both showed a slower disease progression with lower viral load levels and a reduced rate of genetic evolution compared to the patients with normal CCR5 alleles. During 3 years oftreatment-free follow-up, the mean pairwise genetic distance increased with 1.45% and 1.58% in the two patients with a 32-bp deletion allele compared to 3.05% and 3.57% in the two patients with normal CCR5 alleles. The observed relation between slower disease progression and a reduced evolutionary rate illustrates the influence of the virus replicative capacity, here most possibly hampered by the CCR5heterozygosity in two of the four individuals, on the genetic evolution of the virus in the host.

6- Formato FASTA-

CCATGTGTAAAATTAACTCCACTCTGTGTTACTTTAAATTGCACTGATAATTGGAATAGCACTAGAACTG
ATAATTGGAATAACACGGGAAATGTTAATGATAGTAGTGGGGAAAAAGAAATGAAAAATTGCTCTTTCAA
TACCACCCCAAACATAAGAGATAAGGTGCAGAAGGAATATGCACTTTTTTATAAACTTGATGTAGTACCACTAGGAGAAAATGACAATAATAGTTATAGGTTGATAAACTGTAATACCTCAGTCATTACACAGGCCTGTC
CAAAGGTATCCTTTGAGCCAATTCCCATACATTATTGTGCCCCAGCTGGTTTTGCGATTCTAAAGTGTAA
TGATAAGAAGTTCAATGGAACAGGACCATGTACAAATGTCAGCACAGTACAATGTACACATGGAATTAGG
CCAGTAGTGTCAACTCAGCTGCTGTTAAATGGCAGTCTAGCAGAAAAAGAGGTAATAATTAGATCTGAAA
ATATCACAAACAATGCTAAAACTATAATAGTACAGCTGAACGAAACTGTAGAAATTAATTGTACAAGGCC
CAACAATAATACGAGAAAAAGTATACCTATAGGACCAGGAAGAGCATTTTTTGCAACAGGAGCCGTAATAGGAGACATAAGAAAAGCATATTGTACCATTAATAGAGCAAAATGGAATAACACTTTAAGACAGACAGTTA
TAAAATTAAGGGAACAATTTGGGAATAAAACAATAATCTTTAATCAATCCTCGGGAGGGGACCTAGAAAT
TGTAATGCACAGTTTTAACTGTAGAGGGGAATTTTTCTACTGTAATACAACACCACTGTTTAATAGTACT
TGGGGTAGTAATGATAGTATGCCTGAAAATAATACTGGAGGAAATGAAACTATCACACTCCAATGTAAAA
TAAAACAAATTATAAACATGTGGCAGGAAGTAGGAAAAGCAATGTATGCCCCTCCCATCAGCGGACAAAT
TACATGTTTATCAAATATTACAGGGCTACTATTAATAAGAGATGGTGGCAACCAG.

7- FormatoFASTA, Secuencia de aminoácidos-

"PCVKLTPLCVTLNCTDNWNSTRTDNWNNTGNVNDSSGEKEMKNC
SFNTTPNIRDKVQKEYALFYKLDVVPLGENDNNSYRLINCNTSVITQACPKVSFEPIP
IHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEKEVII
RSENITNNAKTIIVQLNETVEINCTRPNNNTRKSIPIGPGRAFFATGAVIGDIRKAYCTINRAKWNNTLRQTVIKLREQFGNKTIIFNQSSGGDLEIVMHSFNCRGEFFYCNTTPL
FNSTWGSNDSMPENNTGGNETITLQCKIKQIINMWQEVGKAMYAPPISGQITCLSNIT
GLLLIRDGGNQ"

8- Los 2 primeros valores de E- 0.0 y 0.0

Los dos primeros organismos-
A) HIV-1 clone C16 from Belgium envelope glycoprotein (env) gene, partial cds
B) HIV-1 clone C12 from Belgium envelope glycoprotein (env) gene, partial cds

2- NM_078692
a- Nombre dela secuencia- Drosophila melanogaster amnesiac (amn), mRNA.

b- Taxonomía- Drosophila melanogaster

c- Función de la secuencia- mRNA

d- Existen referencias- si

Abstract
* The repetitive DNA that constitutes most of the heterochromatic regions of metazoan genomes has hindered the comprehensive analysis of gene content and other functions. We have generated a detailedcomputational and manual annotation of 24 megabases of heterochromatic sequence in the Release 5 Drosophila melanogaster genome sequence. The heterochromatin contains a minimum of 230 to 254 protein-coding genes, which are conserved in other Drosophilids and more diverged species, as well as 32 pseudogenes and 13 noncoding RNAs. Improved methods revealed that more than 77% of this heterochromatin...