Creatinina

Markus Wyss and Rima Kaddurah-Daouk
Physiol Rev 80:1107-1213, 2000.
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PHYSIOLOGICAL REVIEWS
Vol. 80, No. 3, July 2000
Printed in U.S.A.

Creatine and Creatinine Metabolism
MARKUS WYSS AND RIMA KADDURAH-DAOUK
F. Hoffmann-La Roche, Vitamins and Fine Chemicals Division, Basel, Switzerland; Avicena Group,
Cambridge;and Dana Farber Cancer Institute, Division of Cancer Pharmacology, Boston, Massachusetts

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Introduction
Abbreviations
The Physiological Relevance of Creatine: the Creatine Kinase Reaction
CreatineMetabolism in Vertebrates
A. Biosynthesis and tissue uptake of Cr
B. Tissue concentrations and subcellular distribution of Cr and PCr
C. Degradation of Cr and PCr in vertebrates
V. Regulation of Creatine Metabolism in Vertebrates
A. Regulation of L-arginine:glycine amidinotransferase expression and activity
B. Regulation of transport of Cr, PCr, ADP, and ATP across biological membranes
VI....