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Fundamentals of Forensic DNA Typing
This work was funded in part by the National Institute of Justice (NIJ)
through interagency agreement 2008-DN-R-121 with the NIST Office of Law
Enforcement Standards. Points of view in this document are those of the
author and do not necessarily represent the official position or policies of the
U.S. Department of Justice. Certain commercial equipment,instruments, and
materials are identified in order to specify experimental procedures as completely as possible. In no case does such identification imply a recommendation or endorsement by the National Institute of Standards and Technology
nor does it imply that any of the materials, instruments, or equipment identified are necessarily the best available for the purpose.
Completed January 2009 Fundamentals of Forensic
DNA Typing
John M. Butler
National Institute of Standards and Technology
Gaithersburg, Maryland, USA
AMSTERDAM • BOSTON • HEIDELBERG • LONDON • NEW YORK • OXFORD
PARIS • SAN DIEGO • SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO
Academic Press is an imprint of Elsevier
Contribution of the National Institute of Standards and Technology, 2010.
Academic Pressis an imprint of Elsevier
30 Corporate Drive, Suite 400, Burlington, MA 01803, USA
525 B Street, Suite 1900, San Diego, California 92101-4495, USA
84 Theobald’s Road, London WC1X 8RR, UK
Preface © 2010, Elsevier Inc. All rights reserved.
Library of Congress Cataloging-in-Publication Data
Butler, John M. (John Marshall), 1969Fundamentals of forensic DNA typing / John M. Butler.
p. ; cm.Includes bibliographical references and index.
ISBN 978-0-12-374999-4 (pbk. : alk. paper) 1. DNA fingerprinting.
2. Forensic genetics. I. Title.
[DNLM: 1. DNA Fingerprinting—methods. 2. DNA—physiology.
3. Forensic Medicine—methods. W 786 B985f 2010]
RA1057.55.B883 2010
614'.1—dc22
2009009659
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from theBritish Library.
ISBN: 978-0-12-374999-4
For information on all Academic Press publications
visit our Web site at www.elsevierdirect.com
Printed in the United States of America.
09 10 11 12
10 9 8 7 6 5 4 3 2 1
To my parents
who fostered my love for learning,
and to my wife, Terilynne, and six children
who tolerate it.
Companion Web site:http://www.elsevierdirect.com/companions/9780123749994
• Image collection
• Links to useful Web sites
Fundamentals of Forensic DNA Typing
by John M. Butler
Resources for Professors:
• A tailored set of 1000+ PowerPoint slides (including figures)
• Chapter summaries
• A test bank with key
To adopt this book for course use, visit http://textbooks.elsevier.com
Contents
FOREWORD........................................................................................................ ix
INTRODUCTION ................................................................................................ xi
ACKNOWLEDGMENTS ......................................................................................xv
ABOUT THE AUTHOR .................................................................................... xviiCHAPTER 1
Overview and History of DNA Typing .....................................1
CHAPTER 2
Basics of DNA Biology and Genetics ...................................... 19
CHAPTER 3
Historical Methods .................................................................. 43
CHAPTER 4
Sample Collection, Storage, and Characterization ................ 79
CHAPTER 5
DNAExtraction ........................................................................ 99
CHAPTER 6
DNA Quantitation .................................................................. 111
CHAPTER 7
DNA Amplification (The Polymerase Chain Reaction) ....... 125
CHAPTER 8
Short Tandem Repeat Markers .............................................. 147
CHAPTER 9
Fundamentals of DNA...
This work was funded in part by the National Institute of Justice (NIJ)
through interagency agreement 2008-DN-R-121 with the NIST Office of Law
Enforcement Standards. Points of view in this document are those of the
author and do not necessarily represent the official position or policies of the
U.S. Department of Justice. Certain commercial equipment,instruments, and
materials are identified in order to specify experimental procedures as completely as possible. In no case does such identification imply a recommendation or endorsement by the National Institute of Standards and Technology
nor does it imply that any of the materials, instruments, or equipment identified are necessarily the best available for the purpose.
Completed January 2009 Fundamentals of Forensic
DNA Typing
John M. Butler
National Institute of Standards and Technology
Gaithersburg, Maryland, USA
AMSTERDAM • BOSTON • HEIDELBERG • LONDON • NEW YORK • OXFORD
PARIS • SAN DIEGO • SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO
Academic Press is an imprint of Elsevier
Contribution of the National Institute of Standards and Technology, 2010.
Academic Pressis an imprint of Elsevier
30 Corporate Drive, Suite 400, Burlington, MA 01803, USA
525 B Street, Suite 1900, San Diego, California 92101-4495, USA
84 Theobald’s Road, London WC1X 8RR, UK
Preface © 2010, Elsevier Inc. All rights reserved.
Library of Congress Cataloging-in-Publication Data
Butler, John M. (John Marshall), 1969Fundamentals of forensic DNA typing / John M. Butler.
p. ; cm.Includes bibliographical references and index.
ISBN 978-0-12-374999-4 (pbk. : alk. paper) 1. DNA fingerprinting.
2. Forensic genetics. I. Title.
[DNLM: 1. DNA Fingerprinting—methods. 2. DNA—physiology.
3. Forensic Medicine—methods. W 786 B985f 2010]
RA1057.55.B883 2010
614'.1—dc22
2009009659
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from theBritish Library.
ISBN: 978-0-12-374999-4
For information on all Academic Press publications
visit our Web site at www.elsevierdirect.com
Printed in the United States of America.
09 10 11 12
10 9 8 7 6 5 4 3 2 1
To my parents
who fostered my love for learning,
and to my wife, Terilynne, and six children
who tolerate it.
Companion Web site:http://www.elsevierdirect.com/companions/9780123749994
• Image collection
• Links to useful Web sites
Fundamentals of Forensic DNA Typing
by John M. Butler
Resources for Professors:
• A tailored set of 1000+ PowerPoint slides (including figures)
• Chapter summaries
• A test bank with key
To adopt this book for course use, visit http://textbooks.elsevier.com
Contents
FOREWORD........................................................................................................ ix
INTRODUCTION ................................................................................................ xi
ACKNOWLEDGMENTS ......................................................................................xv
ABOUT THE AUTHOR .................................................................................... xviiCHAPTER 1
Overview and History of DNA Typing .....................................1
CHAPTER 2
Basics of DNA Biology and Genetics ...................................... 19
CHAPTER 3
Historical Methods .................................................................. 43
CHAPTER 4
Sample Collection, Storage, and Characterization ................ 79
CHAPTER 5
DNAExtraction ........................................................................ 99
CHAPTER 6
DNA Quantitation .................................................................. 111
CHAPTER 7
DNA Amplification (The Polymerase Chain Reaction) ....... 125
CHAPTER 8
Short Tandem Repeat Markers .............................................. 147
CHAPTER 9
Fundamentals of DNA...
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