Eating behavior and adherence in obese adult subjects treated carlo

Eating behavior and adherence in obese adult subjects treated
Carlo
Maurizio

to dietary prescriptions with 5-hydroxytryptophan1’2
Maria Del Ben, Alessandro Laviano,
Rossi-Fanelli adin obese subjects (14). The present study attempted to confirm

Cangiano,
Muscaritoli,

Fabrizio

Ceci,
Fabiola

Antonia
Antonucci, have (5-HTP) food data adherence 20 obese

Cascino,
and shownintake, over

Filippo that and oral

ABSTRACT
ministration prescriptions of causes

Previous
anorexia,

observations
decreased these

5-hydroxytryptophan To confirm

without a longer

dietary weight period

these data over whether adherence administering

a longer period of observation to dietary restriction could to obese hyperphagic

and to verify be improved by

loss inobese
ofobservation tion could

subjects.

5-HTP

subjects.

and to verify whether be improved by 5-HTP,

to dietary restricpatients were ran-

domly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No diet was prescribed during the first period, a 5040kJ/d diet was recommended in 5-HTP-treated for thesecond. patients Significant during both weight periods.

Subjects
Subjects

and methods
Downloaded from www.ajcn.org by on September 26, 2008

Twenty-eight

obese,

hyperphagic

adult

female

subjects

(mean 30 and of daily

loss was observed

A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the goodtolerance observed suggest that 5-HTP may be safely used to treat KEY obesity. WORDS

age 43.2 y ± I .7: SE) with 40 were studied. Hyperphagia

body mass indexes between was defined as the excess

energy introduced with respect according to sex, age, and physical intolerance, from the hyperlipidemia, study. or

to the energy need calculated activity. Subjects with glucose hyperuricemia wereexcluded

Am J Clin Nutr
Eating obesity, loss behavior, adherence

1992;56:863-7. anorexia, to diet, 5-hydroxytrypappetite for car-

tophan, serotonin, bohydrates, weight

Study The

design research ofthe consent, protocol University subjects was approved by the Faculty Ethics

Introduction
Pharmacological, accumulated rotonin has animals possible genesis this idea and role (5-7).biochemical, and behavioral evidence brain both has sein

Committee informed

of Rome, La Sapienza. were randomly assigned or a placebo composed stearate (both from The drug, which was

After giving to receive

either 5-HTP (900 mg/d) mannitol, and magnesium dustries, capsules per day, subdivided wk periods. tions, during whereas the second Pomezia, Italy).

ofcorn starch, Sigma-Tau Ininthe form of

in the last an inhibitory

two decades, suggesting that influence on eating behavior studies system diseases

in humans ( I -4). Reported played by the serotoninergic present Changes in different in the different deprivation metabolism nutritional producing

in favor of a in the pathofurther support serotonin

that do not dissolve until pH 8.6, was taken three times 30 mmbefore each meal. The 12-wk-study period was for each group of subjects into two consecutive 6During the first period period diet there was were The no dietary 5040 restricsuba 5040-kJ/d recommended to subjects U were

ofanorexia

of brain

in animals experiencing reported (8, 9). Food in serotonin changes stitutes metabolism

states have been a marked increase may reflect in turnconresponses

ofobservation.

in the lateral

hypothalamus

divided as follows: 53% from carbohydrates, and 18% from proteins. No carbohydrate-rich between meals. Subjects were examined every feeding behavior and body measurements were performed weight. Routine for each subject

29% from lipids, foods were allowed 2 wk to evaluate blood chemistry at the beginning

in the availability ofbrain...