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THE

EFFECT OF AN EXCLUSIVE CHEMICAL CONSTITUENTS
BY

MEAT DIET ON THE OF THE BLOOD.*
the

EDWARD

TOLSTOI. Second of

(From

the Russell Medical

Sage Institute of Pathology in Afiliation with (Cornell) Division and Pathological Department Bellevue Hospital, New York.)

(Received for publication, July 12, 1929.) This paper presents the chemical findings in the blood of twonormal men, whose diet for 1 year consisted exclusively of lean and fat meat. While this study was in progress Heinbecker (1) He studied certain published the results of similar experiments. phases of the metabolism of the Baffin Island Eskimos and reported some chemical analyses of the blood. The constituents determined were within normal limits. Because of the lack of facilities where theexperiments were conducted Heinbecker found it necessary to bring the filtrates of the blood to his laboratory in St. Louis where the work was completed. The blood filtrates contained moulds, and though the values for the non-protein nitrogen were normal the results may be questioned, because of certain changes occurring in the filtrates of blood on standing. In both experiments the subjects subsisted onmeat alone, but the composition of the diet was not the same in each instance. Heinbecker’s Eskimos ate about twice as much protein and about half as much fat as the men studied by us. Our subjects consumed about 120 to 130 gm. of protein and enough fat to make a total intake of 2600 to 3000 calories per day. A full description of the experiment of which this is a part will be published by McClellanand Du Bois (2). At the outset it was difficult to decide which chemical constitThe possibility of renal uents of the blood were to be studied. damage suggested, of course, the study of some of the non-protein * This work was in part supported by a grant to the Russell Sage Institute of Pathology by the Institute of American Meat Packers.
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Meat Diet Effect on Blood

nitrogenous substances. The traditional association of meat with uric acid metabolism made the study of the uric acid desirable. As the plasma showed a milkiness soon after the beginning of the experiments, the blood cholesterol was observed. Only a few analyses of the calcium and phosphorus were made. The
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Jan. “ Feb. Mar. “ Apr. “ May June July Aug. Sept. Oct. Nov.
1929

21 25 1 7 23 13 23 28 25 26 25 25 25 26 9 24 15 20

3.:7:1.58107

1.70 92 3.: 5: 100 5 1E 22 4.c )I 1.66 95 9.! 1.70 93 9.1 2c 3.( 31 1.82 111 9.! 4.: 5: 2 1.50 105 1 0.t 1s 5.f 1: 5.: $11.49 91 9.f I 4.: T!1.58 105 Yo analysis made, as s UE eject had 18 4.31.49 96 10.0 4.4 100 3.3 2c 3.01.50105 10.2 3.9 47 10.0 83.5 3.7 45540 Fasted 20 hrs.

1
56.5 60 56.8 55 55

Before diet..

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53 60

Jan. '( Feb. Mar.

-3.21.58105 41 4: 2a 3.01.60110 41 4( 41 3I 21 3.41.60 -

After general diet 4 wks. 87 10.0 3.7 460

COS-combining power was determined because of the ketonuria and its probable effect on the alkali reserve. Analyses of sugar, plasma proteins, and chlorides were also included. Specimens of blood were obtained before the meat diet was instituted. Thereafter specimens were drawn at monthly intervals andalso at t’he close of the experiment. A portion of the

E. Tolstoi

755

oxalated blood was at once precipitated. The remainder was centrifuged in graduated tubes for about 20 minutes. After determining the proportion of plasma to cells the former was drawn off and analyzed. About 10 cc. of whole blood were discharged int’o a test-tube and the serum was used for calcium determination....