Efectos del consumo de manganeso

ehp
ehponline.org

ENVIRONMENTAL HEALTH PERSPECTIVES

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National Institutes of Health U.S. Department of Health and Human Services

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doi: 10.1289/ehp.1002321 (available at http://dx.doi.org/) Online 20 September 2010
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Maryse F. Bouchard, Sébastien Sauvé, Benoit Barbeau, Melissa Legrand, Marie-Ève Brodeur, ThérèseBouffard, Elyse Limoges, David C. Bellinger, Donna Mergler
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Intellectual Impairment in School-Age Children Exposed to Manganese from Drinking Water
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Intellectual Impairment in School-Age Children Exposed to Manganese from Drinking Water

Maryse F. Bouchard1,2, Sébastien Sauvé3, Benoit Barbeau4, Melissa Legrand5, Marie-ÈveBrodeur1, Thérèse Bouffard6, Elyse Limoges7, David C. Bellinger8, Donna Mergler1

1 Centre for Interdisciplinary Studies in Biology, Health, Society and Environment (CINBIOSE),

Corresponding author (mailing address): Dr Maryse Bouchard Centre de recherche, A, bloc 7 CHU Sainte-Justine 3175 chemin de la côte Ste-Catherine Montréal, Québec, Canada, H3T 1C5 Email: maryse.bouchard@umontreal.caEM

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8 Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, United

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7 Department of Pedopsychiatry, Centre Hospitalier de l'Université Laval, Québec, Canada

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6 Department of Psychology, Université du Québec à Montréal, Canada

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5 Healthy Environments and Consumer SafetyBranch, Health Canada, Ottawa, Canada

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Canada

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4 Department of Civil, Geological and Mining Engineering, École Polytechnique de Montréal,

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3 Department of Chemistry, Université de Montréal, Canada

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2 CHU Sainte-Justine Research Center, University of Montreal, Canada

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Université du Québec à Montréal, Canada

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Acknowledgments: The Canadian Institutes for Health Research provided the funding (NRF82899), as well as a fellowship to Maryse Bouchard. We wish to acknowledge the participants who kindly gave their time to help us carry out the study. We have no financial interests to declare. Running head: Water manganese and children’s intellectual quotient Key words: children, manganese,water, neurotoxicity, intellectual quotient Abbreviations:

Intellectual quotient: IQ

World Health Organization: WHO Zinc: Zn

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Wechsler Abbreviated Scale of Intelligence: WASI

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Water manganese concentration: MnW

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Manganese: Mn

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Lead: Pb

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Iron: Fe

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Inductively coupled plasma mass spectrometry: ICP-MS

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Hair manganese concentration: MnH

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Generalized estimating estimations: GEE

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Environmental Protection Agency: EPA

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Copper: Cu

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Confidence interval: CI

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Arsenic: As

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ABSTRACT

Background: Manganese is an essential nutrient, but in excess, can be a potent neurotoxicant. Despite the commonoccurrence of manganese in groundwater, the risks associated with this source of exposure are largely unknown. Objectives: Our first aim was to assess the relations between exposure to manganese from drinking

MnW was associated with a decrease of 2.4 IQ points (95% confidence intervals: -3.9, -0.9; P <

was a 6.2-IQ point difference between children in the lowest and highest MnW quintiles. MnWwas more strongly associated with Performance IQ than Verbal IQ. Conclusions: The findings of this cross-sectional study suggest that exposure to manganese at levels common in groundwater is associated with intellectual impairment in children.

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0.01), adjusting for maternal intelligence, family income, and other potential confounders. There

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