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Elevated concentrations of a certain drug can be maintained in a patient’s body for extended period of time to kill all sensitive cells andinhibit others long enough for the body’s defense to defeat them. Is the extreme use and misuse of antibiotics that are without a doubt the major forces associated with the high numbers of resistantpathogenic and bacteria worldwide. Both the volume and the way antibiotics are applied contribute to the choice of resistant strains. However, other social, ecological, and genetic factors affect a directrelationship between use and regularity of resistance. Resistant bacteria, following their surfacing and evolution in the presence of antibiotics, appear to acquire a “life of their own”.
Theyreproduce and maintain the resistance traits even when antibiotics are not present, in consequence jeopardizing the reversal of bacterial resistance by simple reduction in antibiotic use. Reversingresistance requires restoration of the former susceptible flora in people and in the environment.
This way doctors always remind patients who are given a prescription of antibiotics for theirinfectious disease to take all of their medication until it is finished. Some patients like to stop taking the medication because they “feel better” and no longer find it necessary to finish the whole bottleof antibiotics, when in reality one should finish as indicated by the doctor because discontinuing a drug before all of the pathogens have been neutralized causes the development of resistant...
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