Excreción

Tabla 1. MAUC IV de Cafeína Equipo 2 Urinaria
tu
Vu
Au
Cu
ΔXu
Δt
ΔXu/ Δt
Ln ΔXu/ Δt
10
102
1.6909
37.4801
3822.9702
10
382.2970
5.9461
20
94
1.1738
26.0903
2452.4882
10245.2488
5.5022
30
71
1.0231
22.7709
1616.7339
10
161.6733
5.0855
40
74
0.6284
14.0770
1041.698
10
104.1698
4.6460
60
160
0.3963
8.9647
1434.352
20
71.7176
4.2727
80
138
0.21044.8700
672.06
20
33.603
3.5146
100
98
0.1166
2.8039
274.7822
20
13.7391
2.6202
120
122
0.065
1.6674
203.4228
20
10.1711
2.3195
∞
506
0.044
1.2048
609.6288




Gráfica 1.MAUC IV de Cafeína Equipo 2 Urinaria

Ac= De-Kel*t= (20.02 mg)e –(0.033 hrs-1) (2.33 hrs)= 18.5383 mg
Xu∞= (Kr/Kel)(D)= 6.148 mg*hrs-1/0.033 hrs-1= 186.3030 mg
Kr= (Xu∞*Kel)/D= 0.3070 hrs-1ΔXu/Δt= Ac*Kr= 18.5383 mg * 0.3070 hrs-1= 5.6912 mg*hrs-1
T1/2= ln2/Kr = ln2/0.3070 hrs-1= 2.2578 hrs
Xu= (Kr*D)/(Kel) * (1-e-Kel*t)= (0.3070 hrs-1*20.02 mg)/(0.033 hrs-1) * (1-e(0.033 hrs-1)(2.33hrs))= 13.7837 mg
CFE= Xu∞ - Xu= 186.3030 mg – 13.7837 mg= 172.566 mg

tu
Vu
Au
Cu
ΔXu
Δt
ΔXu/ Δt
Ln ΔXu/ Δt
Ť
3
13
0.3142
7.1563
93.0319
3
31.0106
3.4343
1.5
6
22
1.2083
26.8502590.7044
3
196.9014
5.2827
4.5
9
20
1.5899
35.2555
705.11
3
235.0366
5.4597
7.5
12
18
1.6192
35.9008
646.2144
3
215.4048
5.3725
10.5
15
18
1.5728
34.8788
627.8184
5125.5636
4.8328
13.5
20
28
1.4962
33.1916
929.3648
5
185.8729
5.2250
17.5
25
18
1.41
31.2929
563.2722
5
112.6544
4.7243
22.5
30
42
1.1802
26.2312
1101.7104
10
110.1710
4.702027.5
40
58
1.1182
24.8656
1442.2048
10
144.2204
4.9713
35
50
56
1.0013
22.2907
1248.2792
10
124.8279
4.8269
45
60
58
0.9013
20.0881
1165.1098
10
116.5109
4.7579
55
80
1120.7364
16.4559
1843.0608
20
92.1530
4.5234
70
100
102
0.6883
15.964
1628.328
20
81.4164
4.3995
90
120
102
0.5264
11.8003
1203.6306
20
60.1815
4.0973
110
Tabla 2. MAUC Oral...