Hemato fundamentos

ABC OF CLINICAL HAEMATOLOGY: Second Edition

Edited by DREW PROVAN

BMJ Books

ABC OF CLINICAL HAEMATOLOGY
Second Edition

ABC OF CLINICAL HAEMATOLOGY
Second Edition

Edited by DREW PROVAN
Senior Lecturer, Department of Haematology, Bart’s and the London, Queen Mary’s School of Medicine and Dentistry, London

© BMJ Books 2003 BMJ Books is an imprint of the BMJ Publishing GroupAll rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording and/or otherwise, without the prior written permission of the publishers. First published in 1998 Second edition 2003 by BMJ Books, BMA House, Tavistock Square, London WC1H 9JR www.bmjbooks.com BritishLibrary Cataloguing in Publication Data A catalogue record for this book is available from the British Library ISBN 0 7279 16769 Typeset by Newgen Imaging Systems (P) Ltd., Chennai, India Printed and bound in Spain by GraphyCems, Navarra Cover image: False colour SEM of blood with myeloid leukaemia. Robert Becker/Custom Medical Stock Photo/Science Photo Library.

Contents
Contributors Preface 1Iron deficiency anaemia Drew Provan Macrocytic anaemias Victor Hoffbrand, Drew Provan The hereditary anaemias David J Weatherall Polycythaemia, essential thrombocythaemia, and myelofibrosis George S Vassiliou, Anthony R Green Chronic myeloid leukaemia John Goldman The acute leukaemias T Everington, R J Liesner, A H Goldstone Platelet disorders R J Liesner, S J Machin The myelodysplastic syndromesDavid G Oscier Multiple myeloma and related conditions Charles R J Singer Bleeding disorders, thrombosis, and anticoagulation K K Hampton, F E Preston Malignant lymphomas and chronic lymphocytic leukaemia G M Mead Blood and marrow stem cell transplantation Andrew Duncombe Haematological disorders at the extremes of life Adrian C Newland, Tyrrell G J R Evans Haematological emergencies Drew Provan Thefuture of haematology: the impact of molecular biology and gene therapy Adele K Fielding, Stephen J Russell Index vi vii 1

2

5

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9

4

14

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6

23

7

28

8

33

9

37

10

43

11

47

12

52

13

57

14

61

15

65

71

v

Contributors
Andrew Duncombe Consultant Haematologist, Southampton University Hospitals NHS Trust,Southampton Tyrrell G J R Evans Senior Lecturer, Department of General Practice and Primary Care, King’s College School of Medicine and Dentistry, London T Everington Specialist Registrar, Department of Haematology, University College London Hospitals NHS Trust, London Adele K Fielding Senior Associate Consultant and Assistant Professor in Medicine, Molecular Medicine Program and Division ofHematology, Mayo Clinic, Rochester, MN, USA John Goldman Professor of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London A H Goldstone Consultant Haematologist, Department of Haematology, University College London Hospitals NHS Trust, London Anthony R Green Professor of Haemato-Oncology, Department of Haematology, Cambridge Institute for Medical Research, Cambridge K K HamptonSenior Lecturer in Haematology, Royal Hallamshire Hospital, Sheffield Victor Hoffbrand Emeritus Professor of Haematology and Honorary Consultant Haematologist, Royal Free Hospital Hampstead NHS Trust and School of Medicine, London R J Liesner Consultant Haematologist, Department of Haematology and Oncology, Great Ormond Street Hospital for Children NHS Trust, London, and Department of Haematology,University College London Hospitals NHS Trust, London S J Machin Professor of Haematology, Department of Haematology, University College London Hospitals NHS Trust, London G M Mead Consultant in Medical Oncology, Wessex Medical Oncology Unit, Southampton University Hospitals NHS Trust, Southampton Adrian C Newland Professor of Haematology, Department of Haematology, Bart’s and the London, Queen...