Hipotiroidismo Primario
Páginas: 2 (285 palabras)
Publicado: 14 de marzo de 2013
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Primary hypothyroidism in dogs is associated with elevated GH release
W M Lee, M Diaz-Espineira, J A Mol, A Rijnberk and H S Kooistra
Department ofClinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80·154, NL-3508 TD Utrecht, The Netherlands (Requests foroffprints should be addressed to W M Lee; Email: W.M.Lee@vet.uu.nl)
Abstract The pulsatile secretion patterns of GH were investigated in seven beagle bitches bycollecting blood samples every 10 min for 6 h during euthyroidism and 1·5 years after induction of primary hypothyroidism. Hypothyroidism was induced by surgicalremoval of the thyroid gland and subsequent destruction of any remnant thyroid tissue by oral administration of sodium [131I]iodide. Some of the physical changesobserved in the dogs with primary hypothyroidism mimicked those of acromegaly. During both euthyroidism and hypothyroidism GH was secreted in a pulsatile fashion.The mean ( ...) basal plasma GH concentration was significantly higher (P=0·003) in the hypothyroid state (4·1 1·6 µg/l) than in the euthyroid state (1·2 0·4µg/l). Likewise, the mean area under the curve (AUC) for GH above the zero-level during hypothyroidism (27·0 10·0 µg/l 6 h) was significantly higher (P=0·004) than thatduring euthyroidism (11·7 2·0 µg/l 6 h). The mean AUC for GH above the baseline was significantly lower (P=0·008) during hypothyroidism (2·4 0·8 µg/l 6 h) thanduring euthyroidism (4·5 1·8 µg/l 6 h), whereas there was no significant difference in GH pulse frequency. The mean plasma IGF-I level was significantly higher (P
Primary hypothyroidism in dogs is associated with elevated GH release
W M Lee, M Diaz-Espineira, J A Mol, A Rijnberk and H S Kooistra
Department ofClinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, PO Box 80·154, NL-3508 TD Utrecht, The Netherlands (Requests foroffprints should be addressed to W M Lee; Email: W.M.Lee@vet.uu.nl)
Abstract The pulsatile secretion patterns of GH were investigated in seven beagle bitches bycollecting blood samples every 10 min for 6 h during euthyroidism and 1·5 years after induction of primary hypothyroidism. Hypothyroidism was induced by surgicalremoval of the thyroid gland and subsequent destruction of any remnant thyroid tissue by oral administration of sodium [131I]iodide. Some of the physical changesobserved in the dogs with primary hypothyroidism mimicked those of acromegaly. During both euthyroidism and hypothyroidism GH was secreted in a pulsatile fashion.The mean ( ...) basal plasma GH concentration was significantly higher (P=0·003) in the hypothyroid state (4·1 1·6 µg/l) than in the euthyroid state (1·2 0·4µg/l). Likewise, the mean area under the curve (AUC) for GH above the zero-level during hypothyroidism (27·0 10·0 µg/l 6 h) was significantly higher (P=0·004) than thatduring euthyroidism (11·7 2·0 µg/l 6 h). The mean AUC for GH above the baseline was significantly lower (P=0·008) during hypothyroidism (2·4 0·8 µg/l 6 h) thanduring euthyroidism (4·5 1·8 µg/l 6 h), whereas there was no significant difference in GH pulse frequency. The mean plasma IGF-I level was significantly higher (P
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