Immunobiology

Immunobiology

Table of contents

Short contents Preface to the Fifth Edition Acknowledgments Part I. An Introduction to Immunobiology and Innate Immunity 1. Basic Concepts in Immunology 2. Innate Immunity Part II. The Recognition of Antigen 3. Antigen Recognition by B-cell and T-cell Receptors 4. The Generation of Lymphocyte Antigen Receptors 5. Antigen Presentation to T Lymphocytes PartIII. The Development of Mature Lymphocyte Receptor Repertoires 6. Signaling Through Immune System Receptors 7. The Development and Survival of Lymphocytes Part IV. The Adaptive Immune Response 8. T Cell-Mediated Immunity 9. The Humoral Immune Response 10. Adaptive Immunity to Infection Part V. The Immune System in Health and Disease 11. Failures of Host Defense Mechanisms 12. Allergy andHypersensitivity 13. Autoimmunity and Transplantation 14. Manipulation of the Immune Response Afterword. Evolution of the Immune System: Past, Present, and Future, by Charles A. Janeway, Jr. Appendix I. Immunologists' Toolbox Immunization.

The detection, measurement, and characterization of antibodies and their use as research and diagnostic tools. Isolation of lymphocytes. Characterization of lymphocytespecificity, frequency, and function. Detection of immunity in vivo. Manipulation of the immune system. Appendix II. CD Antigens. Appendix III. Cytokines and Their Receptors. Appendix IV. Chemokines and Their Receptors. Appendix V. Immunological Constants. Biographies Glossary

Full contents Preface to the Fifth Edition Acknowledgments Part I. An Introduction to Immunobiology and Innate Immunity1. Basic Concepts in Immunology The components of the immune system. Principles of innate and adaptive immunity. The recognition and effector mechanisms of adaptive immunity. Summary to Chapter 1. References 2. Innate Immunity The front line of host defense. The complement system and innate immunity. Receptors of the innate immune system. Induced innate responses to infection. Summary to Chapter2.

References Part II. The Recognition of Antigen 3. Antigen Recognition by B-cell and T-cell Receptors The structure of a typical antibody molecule. The interaction of the antibody molecule with specific antigen. Antigen recognition by T cells. Summary to Chapter 3. References 4. The Generation of Lymphocyte Antigen Receptors The generation of diversity in immunoglobulins. T-cell receptorgene rearrangement. Structural variation in immunoglobulin constant regions. Summary to Chapter 4. References 5. Antigen Presentation to T Lymphocytes The generation of T-cell receptor ligands. The major histocompatibility complex and its functions. Summary to Chapter 5. References Part III. The Development of Mature Lymphocyte Receptor Repertoires 6. Signaling Through Immune System Receptors Generalprinciples of transmembrane signaling. Antigen receptor structure and signaling pathways. Other signaling pathways that contribute to lymphocyte behavior. Summary to Chapter 6. References 7. The Development and Survival of Lymphocytes Generation of lymphocytes in bone marrow and thymus.

The rearrangement of antigen-receptor gene segments controls lymphocyte development. Interaction with selfantigens selects some lymphocytes for survival but eliminates others. Survival and maturation of lymphocytes in peripheral lymphoid tissues. Summary to Chapter 7. References Part IV. The Adaptive Immune Response 8. T Cell-Mediated Immunity The production of armed effector T cells. General properties of armed effector T cells. T cell-mediated cytotoxicity. Macrophage activation by armed CD4 TH1cells. Summary to Chapter 8. References 9. The Humoral Immune Response B-cell activation by armed helper T cells. The distribution and functions of immunoglobulin isotypes. The destruction of antibody-coated pathogens via Fc receptors. Summary to Chapter 9. References 10. Adaptive Immunity to Infection Infectious agents and how they cause disease. The course of the adaptive response to infection....