Inhibidores De Hdac6

NEXT

1
HISTONE DEACETYLASE INHIBITORS

DNA
HDAC inhibitor
HDAC enzyme
Acetylated
Lysine
Histone
tetramer

NEXT

2

Chromosomes are made up of DNA, the genetic material of the cell.DNA is wrapped around
Histone proteins, which can be acetylated or deacetylated depending on the action of
enzymes known as Histone Deacetylases (HDACs).

Chromosome

NEXT

2

Chromosomesare made up of DNA, the genetic material of the cell. DNA is wrapped around
Histone proteins, which can be acetylated or deacetylated depending on the action of
enzymes known as Histone Deacetylases(HDACs).

DNA

Chromosome

NEXT

2

Chromosomes are made up of DNA, the genetic material of the cell. DNA is wrapped around
Histone proteins, which can be acetylated or deacetylateddepending on the action of
enzymes known as Histone Deacetylases (HDACs).

Histones

DNA

Chromosome

NEXT

3

Histone Deacetylases (HDACs) are also known as Lysine Deacetylases (LDACs),since
several isoforms are also present in the cell cytoplasm, where they exert their action on Lys
residues found on proteins other than histones.

Histones

Nucleus

HDAC6

Microtubules

4NEXT

HDAC6 binds to microtubules in the cytoplasm and takes part in several processes, such as
unfolded protein elimination via aggresome/proteasome pathway. HDAC6 inhibition is related
tocancer cell death and treatment of inflammatory and autoimmune diseases.

Histones

Nucleus

HDAC6

Microtubules

NEXT

5

In the presence of an HDAC inhibitor, histone proteins becomehyperacetylated; DNA loosens
from histone tetramers, and, in general, gene transcription is activated. Also, misfolded protein
elimination is inhibited due to blockage of the aggresome/proteasomepathway.

HDAC inhibitor
HDAC enzyme
Acetylated
Lysine
Histone
tetramer

Histone hyperacetylation

NEXT

6

In the absence of an HDAC selective inhibitor, histone proteins become...