Los 13 errorres que incurren los gerentes

CLINICAL MICROBIOLOGY REVIEWS, July 1998, p. 480–496 0893-8512/98/$04.00 0

Vol. 11, No. 3

Dengue and Dengue Hemorrhagic Fever
DUANE J. GUBLER* Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, P.O. Box 2087, Fort Collins, Colorado 80522INTRODUCTION .......................................................................................................................................................480 EMERGENCE OF DENGUE AS A GLOBAL PUBLIC HEALTH PROBLEM ................................................480 Factors Responsible for the IncreasedIncidence...............................................................................................481 Dengue in the Continental United States ...........................................................................................................482 NATURAL HISTORY.................................................................................................................................................483 The Viruses..............................................................................................................................................................483 Transmission Cycles...............................................................................................................................................484 CLINICALDIAGNOSIS............................................................................................................................................485 Dengue Fever ...........................................................................................................................................................485 Dengue Hemorrhagic Fever...................................................................................................................................486PATHOGENESIS........................................................................................................................................................486 Pathology..................................................................................................................................................................487 Virologic Factors.....................................................................................................................................................487 Host Immune Factors.............................................................................................................................................488 LABORATORYDIAGNOSIS....................................................................................................................................488 Serologic Diagnosis.................................................................................................................................................488 Virus Isolation.........................................................................................................................................................490 Babymice.............................................................................................................................................................490 Mammalian cell culture.....................................................................................................................................490 Mosquitoinoculation..........................................................................................................................................490 Mosquito cell culture..........................................................................................................................................490 Virus Identification.................................................................................................................................................490 New Diagnostic Technology...