Medico

ISSN 0891-4168, Molecular Genetics, Microbiology and Virology, 2008, Vol. 23, No. 2, pp. 63–70. © Allerton Press, Inc., 2008.
Original Russian Text © O.B. Ogarkov, V.V. Sinkov, T.V. Medvedeva, M.Yu.Gutnikova, O.M. Nekipelov, L.Yu. Raevskaya, N.Yu. Kuptsevich, K.Yu. Kostyunin, R.G. Skvortsova,
2008, published in Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, 2008, No. 2, pp. 12–17.EXPERIMENTAL
ARTICLES

Polymorphism of Genes of the Renin–Angiotensin System ACE,
ATIR, and AT2R in Patients with Pulmonary Tuberculosis
O. B. Ogarkova, V. V. Sinkova, T. V. Medvedevaa, M. Yu.Gutnikovaa, O. M. Nekipelovb,
L. Yu. Raevskayaa, N. Yu. Kuptsevichc, K. Yu. Kostyunina, and R. G. Skvortsovaa
a Irkutsk

Regional Diagnostic Center, Irkutsk, Russia
Regional Anti-TuberculosisHospital, Irkutsk, Russia
c Irkutsk City Anti-Tuberculosis Hospital, Irkutsk, Russia

b Irkutsk

Received February 20, 2007

Abstract—The investigation was aimed at testing the hypothesis on thepossible role of some genes of the
renin–angiotensin system in the formation of innate immunity to tuberculosis. It is known that insertion–deletion (I/D) polymorphism of the gene encoding theangiotensin-converting enzyme (ACE) influences the concentration of angiotensin II in the human organism and, indirectly, many stages of metabolism. On one hand,
homozygotes of deletion in the ACE gene (DDgenotype) are characterized with obesity, arterial hypertension,
hypocholesterolemia, and some other pathological conditions. On the other hand, it was demonstrated that
hypercholesterolemia is commonpathology for patients with pulmonary tuberculosis (C. Perez-Guzman et al.,
2005).
The investigation of insertion–deletion polymorphism of the ACE gene (genotypes DD, ID and II), single nucleotidepolymorphism at position 1166 of the AT1R gene (1166 A/C), and analogous transversion at position 3123
of the AT2R gene (3123 A/C) was carried out. A group of 200 patients with tuberculosis 202...