Metabolismo
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|Maternal vitamin D deficiency increases the risk of preeclampsia|
|Bodnar, L.M.; Catov, J.M.; Simhan, H.N.; Holick, M.F.; Powers, R.W.; Roberts, J.M. |
|Vol: 92 Nro: 9 Págs:3517 - 3522 Fecha: 01/09/2007 |
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|Resumen |
|Context: Vitamin D hasdirect influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet|
|the vitamin D-preeclampsia relation has not been studied. Objectives: We aimed to assess theeffect of maternal |
|25-hydroxyvitamin D [ 25( OH) D] concentration on the risk of preeclampsia and to assess the vitamin D status of newborns of |
|preeclamptic mothers. Design andSetting: We conducted a nested case-control study of pregnant women followed from less than 16|
|wk gestation to delivery ( 1997-2001) at prenatal clinics and private practices. Patients: Patientsincluded nulliparous |
|pregnant women with singleton pregnancies who developed preeclampsia ( n = 55) or did not develop preeclampsia ( n = 219). |
|Women's banked sera were newly measuredfor 25( OH) D. Main Outcome Measure: The main outcome measure was preeclampsia ( |
|new-onset gestational hypertension and proteinuria for the first time after 20 wk gestation). Our hypotheses...
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