Metaloproteasas

Critical Reviews in Biochemistry and Molecular Biology, 37(6):375–536 (2002)

Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
Philippe E. Van den Steen,1 Bénédicte Dubois,1 Inge Nelissen,1 Pauline M. Rudd,2 Raymond A. Dwek,2 and Ghislain Opdenakker1
Rega Institute for Medical Research, University of Leuven, Belgium; 2The Glycobiology Institute,University of Oxford, UK
* Correspondence to Ghislain Opdenakker, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10. B-3000 Leuven, Belgium. e-mail: ghislain.opdenakker@rega.kuleuven.ac.be
1

Abbreviations Aβ1-40, amyloid-β peptide (1-40); ALS, amyotrophic lateral sclerosis; AP-1/2, activating protein-1/ 2; APMA, 4-aminophenylmercuric acetate; ARDS, Acute RespiratoryDistress Syndrome; ASK1, apoptosis signal-regulating kinase 1 or MEKK5; ATF, activating transcription factor; Bcl-2, B-cell lymphoma proto-oncogene-2; bFGF, basic fibroblast growth factor; c-, cellular; CAM, cell adhesion molecule; cAMP, adenosine-3’,5’-cyclic monophosphate; Cdc42, cell division cycle 42 protein; ConA, concanavalin A; cPLA2, cytoplasmatic phospholipase A2; CREB, cAMP responseelement binding protein; CTAP-III, connective tissue activating peptide-III; DAG, diacylglycerol; E1A, adenovirus type A early gene; EAE, experimental autoimmune encephalomyelitis; ECM, extracellular matrix; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; ERB, EGF receptor B; ERK, extracellular signal-regulated kinase; ET-1, endothelin-1; Ets, E26 avian erythroblastosis virusproto-oncogene; FAK, focal adhesion kinase; fMLP, formyl-methionylleucyl-phenylalanine; GAS, gamma interferon-activated sequence; GCP-2, granulocyte chemotactic protein-2; Gp, glycoprotein; GRO-α, growth-related oncogene-α; GTPase, guanosine triphosphatase; HGF/SF, hepatocyte growth factor/scatter factor; HIV, human immunodeficiency virus; HTLV-1, human T-cell lymphotropic virus-1; ICAM-1,intercellular cell adhesion molecule-1; IFN, interferon; IFNAR, IFN-α/β receptor; ISRE, IFN-stimulated regulatory element; IKK, IκB kinase; IL-, interleukin-; JAK, Janus-protein tyrosine kinase; JNK/SAPK, c-jun N-terminal kinase/stress-activated protein kinase; LFA-1, lymphocyte function-associated antigen-1; LPS, lipopolysaccharide; LTB4, leukotriene B4; MAPK, mitogen-activated protein kinase; MAPKAPK,MAPK-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK/MKK, MAPK/ERK kinase; MEKK, MEK kinase; MMP, matrix metalloproteinase; MPO, myeloperoxidase; MT-MMP, membrane-type MMP; NF-κB, nuclear factor-kappa B; NGAL, neutrophil gelatinase B-associated lipocalin; NIK, NF-κB-inducing kinase; PDGF, platelet-derived growth factor; PEA3, polyomavirus enhancer A-binding protein-3; PECAM,platelet endothelial cell adhesion molecule; PF-4, platelet factor-4; PGE2, prostaglandin E2; PI-3K, phophatidylinositol 3-kinase; PKA, protein kinase A; PKC, protein kinase C; PMA, phorbol 12myristate 13-acetate; PTK, protein tyrosine kinase; Ras, rat sarcoma oncogene; RBE, retinoblastoma binding element; RGD, Arg-Gly-Asp; RTK, receptor tyrosine kinase; SCC, squamous cell carcinoma; SDF-1,stromal-cell derived factor-1; SDS-PAGE, sodium dodecyl sulfate polyacryla1040-9238/02/$.50 © 2002 by CRC Press LLC

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mide gel elctrophoresis; SH, Src homology; Smad, similar to mothers against decapentaplegic homolog; SNP, single nucleotide polymorphism; Sp1, stimulating protein-1; SPF, specific pathogen-free; Src, Rous sarcoma protooncogene; STAT, signal transducer and activator oftranscription; TAK1, TGF-β activated kinase-1; TFPI, tissue factor pathway inhibitor; TGF-β, transforming growth factor-β; TIE, TGF-β1 inhibitory element; TIMP, tissue inhibitor of metalloproteinases; TNF-α, tumor necrosis factor-α; t-PA, tissue-type plasminogen activator; TPA, 12-O-tetradecanoylphorbol-13-acetate; TRE, TPA response element; u-PA, urokinase; v-, viral; VCAM-1, vascular cell adhesion...