Mora Hipoglicemiante

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Archives of Physics Research, 2011, 2 (4):72-79
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ISSN : 0976-0970 CODEN (USA): APRRC7

UV-Visible and infrared analysis of commercial drug and its mixtures
S. Karthikeyan Department of Physics, St. Jospeh’s College of Engineering, Chennai, Tamil Nadu, India______________________________________________________________________________ ABSTRACT The study of characterization of commercial drug was made through spectroscopic technique. Chloramphenicol and Ranitidine is the commercial drug mostly used for the treatment of bone marrow depression and mycrocytic-anemia. Many researches have been made on structural characterization of this commercial drug. Theuse of this drug interaction with spectroscopic study has been made to find the possible influence of one drug over the other. Key Words: FTIR, UV study, commercial drug, characterization. ______________________________________________________________________________ INTRODUCTION Pharmacology can be defined as the branch of science that includes history, source, physicochemical properties, dosageforms, methods of administration, absorption, distribution, mechanism of action, physiological and biochemical changes produced within the body, biotransformation and excretion, clinical uses, and adverse effects of the drugs. There is some structure activity relationship with the drug. The activity of drug is intimately related to its chemical structure. Knowledge about the chemical structure adrug is useful for Synthesis of new compounds with more specific actions and fewer adverse reactions and understanding the mechanism of drug action [1]. The main objective of pharmaceutical drug analysis is to offer not only a ready reference, but also an intermediate level for the convenient analysis of pure pharmaceutical substances and their respective dosage forms wherever applicable.Spectroscopy has recently emerged as a novel bio-medical technique that can potentially reveal a wealth of qualitative and quantitative information about a given pharmaceutical sample. The increasing use of FT-IR spectroscopy demonstrates that this technique is a valuable tool owing to its high sensitivity in detecting changes in functional groups of tissue components, such as membranes, Proteins nucleicacids, as well as for complex drug material. When infrared light is passed through a sample of an organic compound some of the frequencies are absorbed while the others are transmitted. The variation of infrared absorbance against frequency gives the infrared spectrum. The infrared spectrum of a compound is essentially the superposition of absorption bands of specific functional groups. Forqualitative analysis, the 72 Scholars Research Library

S. Karthikeyan Arch. Phy. Res., 2011, 2 (4): ______________________________________________________________________________ absorptions in specific frequency regions can be correlated with specific stretching and bending motions of these groups. Thus by interpreting of the spectrum it is possible to state whether certain functional groups arepresent or not in a given sample material. Many researches have been carried out to study the structural characterization of drugs using spectroscopic study [2-5]. .Keeping in view of this above facts an attempt has been made to study. (1) Structural conformation and to assign the frequencies of different functional group of commercial tablet Chloramphenicol and Ranitidine using FTIR technique. (ii)To find the absorption position in UV-Visible spectrum, and to find any interaction existing among the drugs. MATERIALS AND METHODS 2.1. Description of Chloramphenicol commercial drug The molecular formula of Chloramphenicol is C11H12Cl2N2 O5 having the structure as

The use of chloramphenicol has been shown to cause bone marrow depression. This toxicity is usually reversible if the drug is...