Neuritis óptica

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Rev Neurol (Paris). Author manuscript; available in PMC 2010 December 21.
Published in final edited form as: Rev Neurol (Paris). 2010 December ; 166(12):978–986. doi:10.1016/j.neurol.2010.03.024.

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Optical Coherence Tomography (OCT) in Optic Neuritis and Multiple Sclerosis1Department 2Department 3Department

Cédric Lamirel, MD1, Nancy J. Newman, MD1,2,3, and Valérie Biousse, MD1,2 of Ophthalmology, Emory University School of Medicine. Atlanta, GA. USA of Neurology, EmoryUniversity School of Medicine. Atlanta, GA. USA of Neurological Surgery, Emory University School of Medicine. Atlanta, GA. USA

Abstract
Optical coherence tomography (OCT) is a non-invasive imagingtechnique routinely used in ophthalmology to visualize and quantify the layers of the retina. It also provides information on optic nerve head topography, peripapillary retinal nerve fiber layerthickness, and macular volume which correlate with axonal loss. These measurements are of particular interest in optic neuropathies and in multiple sclerosis, and OCT parameters are now used as endpoints inneurologic clinical trials.

Keywords Optical Coherence Tomography; névrite optique; sclérose en plaques Originally developed for retinal diseases and glaucoma, optical coherence tomography (OCT)allows direct visualization and measurement of the optic nerve head topography, and of retinal nerve fiber layer (RNFL) thickness with micron-scale resolution (Sakata et al., 2009). Quantification ofthe RNFL thickness by OCT provides an indirect measure of axonal and neuronal loss in the anterior visual pathways. The RNFL thickness is of particular interest in optic neuropathies and in numerousneurologic disorders such as multiple sclerosis (MS) (Barkhof et al., 2009; Frohman et al., 2008a; Frohman et al., 2008b; Sergott et al., 2007). Because OCT is noninvasive, easy to obtain, and...