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Páginas: 2 (270 palabras) Publicado: 16 de septiembre de 2012
Julio Vazquez mellado
A01176344

WHAT IS A PRION?
A “Prion” is an infectious agent that is composed primarily of protein. To date, all such agents that have beendiscovered propagate by transmitting a mis-folded protein state; the protein itself does not self-replicate and the process is dependent on the presence of the polypeptide in thehost organism. The mis-folded form of the prion protein has been implicated in a number of diseases in a variety of mammals, including bovine spongiform encephalopathy (BSE, alsoknown as "mad cow disease")
http://www.news-medical.net/health/What-is-a-Prion.aspx
HOW WAS IT DISCOVERED?
During the 1960s radiation biologist Tikvah Alper andmathematician John Stanley Griffith developed the hypothesis that some transmissible spongiform encephalopathies are caused by an infectious agent consisting solely of proteins. Theirtheory was developed to explain the discovery that the mysterious infectious agent causing the diseases scrapie and Creutzfeldt–Jakob disease resisted ionizing radiation. In 1982,Stanley B. Prusiner of the University of California, San Francisco announced that his team had purified the hypothetical infectious prion, and that the infectious agent consistedmainly of a specific protein – though they did not manage to isolate the protein until two years after Prusiner's announcement
http://en.wikipedia.org/wiki/Prion

3 EXAMPLESOF PRIONS
1. KURU: infectious; in humans who practiced cannibalism in Papua New Guinea
2. Gerstmann-Sträussler-Scheinker disease:inherited disease of humans
3.Scarpie: infectious disease of sheep and goats
These are three examples of prions and there ase a few more.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Prions.html
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