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Ortiz JF et al. Tratamiento de úlceras corneales en caninos

Revista Colombiana de Ciencias Pecuarias

Comparison of autologous serum with a commercial product
as an adjunct in the treatment of uncomplicated corneal
ulceration in dogs¤
Comparación de suero autólogo con un producto comercial como complemento en el
tratamiento de úlceras corneales no complicadas en caninos
Comparaçãode soro autólogo com um produto comercial, como adjuvante no tratamento de
úlcera de córnea não complicada em cães
José F Ortiz1,2*, MV, Esp; Sandra P Acevedo2, MV, Esp, cMSc; Luis F Restrepo B2, Esp.
Grupo de Investigación GIVET, Facultad de Ciencias Administrativas y Agropecuarias,Corporación Universitaria Lasallista, AA 50130,
Caldas, Antioquia, Colombia; 2Grupo de investigación CENTAURO,Facultad de Ciencias Agrarias,
Universidad de Antioquia, AA 1226, Medellín, Colombia.

1

(Recibido: 19 abril, 2010; aceptado: 15 septiembre, 2011)

Summary
Corneal ulcers are among the most common presentations of ocular ailments in dogs. Objective: this
study compares the efficacy of a commercial ointment based on vitamin A, E and hydrolyzed casein, with
the use of autologous serumeyedrops in the re-epithealization of uncomplicated corneal ulcers. Methods:
forty-one dogs with superficial corneal ulcers, and otherwise healthy, were enrolled in the study and
randomly allocated into two groups. They all received standard therapy based on antimicrobial eye drops
of ciprofloxaxin and use of an Elizabethan collar. With prior owner consent, blood samples were taken
from group A,allowed clotting, and serum separated and stored in sterile containers for use topically
on the affected eye. In addition to the standard therapy, patients received either 2 drops of autologous
serum (group A) or 1 cc of the re-epitelializing ointment (group B) every hours 6 hours, and 10 minutes
following the antimicrobial drops. Healing was monitored by measuring the wound size with caliperson
days 3 and 7 of the follow-up, and a Mann-Whithey test was used to compare both groups (SAS, version
9.1). Results: no significant differences were observed between groups in the re-epithelization process. On
day 3, the reduction of the disepithelialized area was 1.47 ± 1.42 and 1.26 ± 0.99 mm for groups A and
B, respectively. By day 7, the average decrease was 0.94 ± 0.77 and 1.42 ± 1.21mm for groups A and B,
respectively. Conclusion: autologous serum was as effective as a commercial re-epithelializing ointment to
treat uncomplicated corneal ulcer in dogs.
Key words: dog, ophthalmology, serum autologous, corneal ulcer.
¤ Para citar este artículo: Ortiz JF, Acevedo SP, Restrepo LF. Comparación de suero autólogo con un producto comercial como complemento en el tratamiento
deúlceras corneales no complicadas en caninos. Rev Colomb Cienc Pecu 2012; 25:90-96.
* Autor para correspondencia: José F Ortiz. Facultad de Ciencias Agrarias, Universidad de Antioquia, AA 1226, Medellín, Colombia. E-mail: cvgenesis1@
yahoo.com.ar.

Rev Colomb Cienc Pecu 2012; 25:90-96

Ortiz JF et al. Tratamiento de úlceras corneales en caninos

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Resumen
Las afecciones del globoocular son frecuentes en pequeños animales, siendo la úlcera corneal una de
las presentaciones más comunes. Objetivo: en este trabajo se comparó la eficacia del suero autólogo frente
a un ungüento oftálmico a base de vitaminas A, E y caseína hidrolizada, en el tiempo de reepitelización
de ulceras no complicadas en caninos. Métodos: para el estudio se formaron dos grupos aleatorios de
21 pacientescada uno, que presentaban ulceras superficiales en grado I y II. Previo consentimiento del
propietario, al grupo A se extrajo sangre para obtención del suero que posteriormente se aplicaría en forma
de gotas tópicas en el ojo afectado. Ambos grupos recibieron terapia estándar antimicrobiana en forma
de gotas de ciprofloxaxina y uso de collar isabelino. A los 10 minutos de instalar el...