sintesis de acido o-iodobenzoico

Sintesis de acido antranilico.
Prepare a solution of 30 g of sodium hydroxide in 120 ml of water in a 350 ml conical flask and cool to 0°C or below in a bath of ice and salt. Add 26.2g (8.4 ml,0.16 mol) of bromine in one portion and shake (or stir) until all the bromine has reacted. The temperature will rise somewhat; cool again to 0°C or below. Meanwhile, prepare a solution of 22g of sodiumhydroxide in 80ml of water. Add 24g (0.163 mol) of finely powdered phthalamide in one portion to the cold sodium hypobromite solution in the form of a smooth paste with water, rapidly with stirring.Remove the flask from the cooling bath and shake vigorously until a clear yellow solution is obtained (c. 5 minutes). Add the prepared sodium hydroxide solution rapidly and in one portion, heat thesolution to 80°C for about 2 minutes and filter if necessary.
Cool in ice and add concentrated hydrochloric acid slowly and with stirring until the solution is just neutral (about 60ml are required).(It is recommended that a little of the alkaline solution be set aside in case too much acid is added). Precipitate the anthranilic acid completely by the gradual addition of glacial acetic acid(20-25 ml are required): it is advisable to transfer the mixture to a 1-litre beaker as some foaming occurs. Filter off the acid at the pump and wash with a little cold water. Recrystallize from hot waterwith the addition of a little decolourising carbon; collect the acid on a Buchner funnel and dry at 100°C. The yield of pure anthranilic acid, m.p. 145°C, is 14g (62%).
Preparar una solución de 30 gde hidróxido de sodio en 120 ml de agua en un matraz cónico de 350 ml y se enfría a 0 ° C o menos en un baño de hielo y sal. Añadir 26,2 g (8,4 ml, 0,16 mol) de bromo en una porción y se agita (orevolver) hasta que todo el bromo ha reaccionado. La temperatura se elevará un tanto; enfriar de nuevo a 0 ° C o por debajo. Mientras tanto, preparar una solución de 22 g de hidróxido de sodio en 80 ml...