Valores De Laboratorio

Reference Ranges for Adults and Children Heil/Ehrhardt · Reference Ranges for Adults and Children 2008

Pre-Analytical Considerations 2008

11322524001 ➇ 608 –

www.roche.de

W. Heil V. Ehrhardt

Roche Diagnostics GmbH 68298 Mannheim Germany

Preface, 9th Edition

In order to fulfill increased regulatory standards the contents of this brochure are now to orientate closer by theinformation included in the package inserts of Roche Diagnostics test kits. As a consequence a number of changes and modifications concerning the indicated reference ranges as well as the citated literature turned out to be necessary. The resulting number changes compared to the 8th edition of this brochure necessitated the publication of a revised 9th edition. As a result of differing printingdates, it is possible that differences may occur between the information given here and that appears in the package inserts. In such cases the data given in the insert, enclosed with the kit, applies. The reference ranges listed in this brochure are guide values which may depend on the specific method used. Therefore, each laboratory should investigate the transferability of the expected values to itsown patient population and if necessary determine its own reference ranges. PD Dr. W. Heil, Wuppertal Dr. V. Ehrhardt, Mannheim Mannheim, March 2008

Authors Dr. Wolfgang Heil, Wuppertal Dr. Volker Ehrhardt, Roche Diagnostics GmbH, Mannheim ° Roche Diagnostics GmbH Status: July 2008
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Contents

Page List of abbreviations 1 1.1 1.2 1.3 1.4 2 2.1 2.2 2.3 2.4 2.5 2.6.1 2.6.2 2.7 2.8 2.9 2.102.11 2.12 2.13 3 3.1 3.2 3.3 3.4 3.5 Pre-analytical considerations Factors affecting blood collection Sample collection Transport and storage of sample material Assessment of sample material Reference ranges Clinical chemistry and immunological tests, serum/plasma Hematology Coagulation Blood gases Therapeutic drug monitoring Urinalysis, urinary sediment and status Clinical chemical urinalysisUrinary calculi, gallstones CSF Stool Spermiogram Extravascular body fluids Function tests Characteristic analytes for identification of body fluids Decision supports Enzyme patterns Lipids Electrophoretic patterns of plasma proteins Schematic representation of blood coagulation Thrombophilia, risk factors 4 7 8 9 10 12 14 14 76 86 100 102 108 112 120 122 124 126 128 137 144 145 145 146 147 149 1503.6 3.7 Age dependence of immunoglobulin synthesis Complement system, classical and alternative mechanism 3.8 Tumor markers 3.9 Serological diagnosis of hepatitis A and B 3.10 Urinary sediment 3.11 Nomogram for diagnosing acid-base disorders 4 4.1 4.2 5 6 7 Conversion tables Conversion table from conventional units to SI units and vice versa (/U refers to urinalysis) Conversion factors for enzymeactivities: U/L « mkat/L and nkat/L Sample stability References List of key words

Page 152 153 154 155 156 158 159 159 171 172 189 225

COBAS; CARDIAC M; INTEGRA; ELECSYS; REFLOTRON; Roche CARDIAC und TINA-QUANT sind Marken von Roche.

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List of abbreviations

BSA C4bBP CA CO2 CSF CTAD d DGKC EDTA EGTA ELISA Eq f g

h H2 Hb Hct (PCV) HPLC IFCC INR IU kat

Body surface areaC4-binding Protein Tumour-related carbohydrate antigen Carbon dioxide Cerebrospinal fluid Citrate, theophylline, adenosine, dipyridamole Day German Society of Clinical Chemistry Ethylene diamine tetraacetic acid 1,2-bis (2-amino ethoxyethane)tetraacetic acid Enzyme-linked immuno-sorbent assay Equivalent mEq milliequivalent Female Gram mg Milligram (10–3 g) mg Microgram (10–6 g) ng Nanogram (10–9 g)pg Picogram (10–12 g) Hour Hydrogen Hemoglobin Hematocrit (packed cell volume) High pressure liquid chromatography International Federation of Clinical Chemistry International Normalized Ratio International Unit Katal mkat Millikatal (10–3 kat) mkat Microkatal (10–6 kat) nkat Nanokatal (10–9 kat) pkat Picokatal (10–12 kat)

L

m m

MCH MCHC MCV mil min mol

mosmol mth NACB NCEP NGSP O2...