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diMultiMode PicoForce Industry-Leading Force-Measurement System

• New High-Speed NanoScope Controller • Tactile Feedback of Tip-Sample Interactions • Low-Noise Detection of Cantilever Deflection

diMultiMode PicoForce
The Leader for Performance, Precision and Resolution

Advanced Force-Curve Performance and Unlimited Extendibility

The NEWMultiMode® PicoForce™ scanning probe microscope system brings unprecedented accuracy and performance to molecular biology and nanoscale materials research. With its innovative force-measurement features, proven SPM technology, and new high-speed fifth-generation controller, the MultiMode PicoForce is ideally suited for a broad variety of studies, from protein unfolding and antigen-antibody binding tomembrane elasticity and Van der Waals forces. New high-performance NanoScope® V controller Measures tip-sample/cantilever dynamics (50MHz data capture) Reduces time spent looking for features (5120 x 5120 pixel density) Displays and acquires eight images simultaneously Closed-loop Z axis with capacitive sensor Delivers accurate, low-noise measurement of extension in force curves PicoAngler™ tactilesensation Permits intuitive interpretation of molecular force interactions

The MultiMode PicoForce system offers the best of both worlds: precise force measurements and high-resolution scanning. The patented PicoForce scanner incorporates a closed-loop Z axis with a vertical range of 20 microns and an X-Y scan size of greater than 40 microns. While competing “sensored” scanners merely measure thecommon problems of piezo creep, hysteresis, and nonlinearity, the PicoForce scanner completely eliminates them, permitting unprecedented accuracy and precision in nanoscale research. This enables force measurements that are simply not possible with open-loop Z axis scanners. When used in conjunction with our full line of MultiMode open-loop scanners, however, the PicoForce system is still able tooffer the highest-resolution scanning available. MultiMode SPMs have always held the distinction of delivering the best resolution in the industry due to a host of resolutionenhancing design features. With the MultiMode PicoForce, you can easily switch between the PicoForce scanner and standard MultiMode scanners to best match the system’s capabilities to your experiment’s demands.

than allcompetitive SPMs combined. The MultiMode platform offers the entire range of SPM techniques for measuring surface characteristics and provides unlimited extendibility to the PicoForce system through a wide selection of imaging modes. The modular design of the PicoForce makes it simple for existing MultiMode SPM users to upgrade.

Innovative Operational Features
The new, handheld PicoAngler allowsthe user to manually explore tip-sample interactions with unprecedented ease. This innovative tool is particularly useful for single-molecule force spectroscopy, providing highly sensitive approach and retraction of the cantilever tip. Via its force-feedback feature, the PicoAngler enables the user to "feel" the force of interaction (e.g., of a molecule stretching and then suddenly unfolding).Four different levels of sensitivity for manual control of the Z axis and force-feedback allow exploration of interactions over a wide range of distances and forces. In addition, the MultiMode PicoForce system includes a low-noise state-of-theart SPM head that dramatically reduces the periodic noise that sometimes appears in force curves on standard SPM systems. This is a crucial benefit sinceperiodic noise can interfere with force spectroscopy measurements in the pico-Newton range. Unlike competitors’ systems, the MultiMode PicoForce utilizes a fully automatic, proprietary tip approach that prevents tip-damaging collisions between the probe and the sample surface.

The World’s Most-Proven SPM Platform
The MultiMode PicoForce system is built around the proven performance of the...