Aporfina

aporfina
Apomorphine
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Apomorphine |
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Systematic (IUPAC) name |(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol |
Identifiers |
CAS number | 41372-20-7 |
ATC code | G04BE07 N04BC07 |
PubChem | CID 6005 |
IUPHAR ligand | 33 |
DrugBank | APRD00531 |
ChemSpider | 5783 Y |
UNII |F39049Y068 Y |
KEGG | D07460 Y |
ChEMBL | CHEMBL53 N |
Chemical data |
Formula | C17H17NO2  |
Mol. mass | 267.322 g/mol |
SMILES | eMolecules & PubChem |
InChI[show] *InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 Y
Key: VMWNQDUVQKEIOC-CYBMUJFWSA-N Y |
Pharmacokinetic data |
Bioavailability | 100%following sc injection |
Protein binding | ~50% |
Metabolism | Hepatic |
Half-life | 40 minutes (range 30-60 minutes) |
Therapeutic considerations |
Pregnancy cat. | C |
Legal status | ℞Prescription only |
Routes | Oral, SC |
 N(what is this?)  (verify) |
Apomorphine (Apokyn, Ixense, Spontane, Uprima) is a non-selective dopamine agonist which activates both D1-like and D2-likereceptors, with some preference for the latter subtypes.[1] It is historically a morphine decomposition product by boiling with concentrated acid, hence the -morphine suffix. Apomorphine does not actuallycontain morphine or its skeleton, or bind to opioid receptors for that matter. The apo- prefix relates to it being an aporphine derivative.
Historically, apomorphine has been tried for a variety ofuses including psychiatric treatment of homosexuality in the early 20th century, and more recently in treating erectile dysfunction. Currently, apomorphine is used in the treatment of Parkinson'sdisease. It is a potent emetic (i.e. it induces vomiting) and should not be administered without an antiemetic such as domperidone. The emetic properties of apomorphine are exploited in veterinary...