Oral zinc for treating diarrhoea in children.pdf

Oral zinc for treating diarrhoea in children (Review)
Lazzerini M, Ronfani L

This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2008, Issue 3 http://www.thecochranelibrary.com

Oral zinc for treating diarrhoea in children (Review) Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.TABLE OF CONTENTS HEADER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . OBJECTIVES . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 3. . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 4. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 6. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CHARACTERISTICS OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DATA AND ANALYSES . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . Analysis 1.1. Comparison 1 Zinc vs placebo for acute diarrhoea, Outcome 1 Diarrhoea duration (h). . . . . . . Analysis 1.2. Comparison 1 Zinc vs placebo for acute diarrhoea, Outcome 2 Diarrhoea on day 3. . . . . . . . Analysis 1.3. Comparison 1 Zinc vs placebo for acute diarrhoea, Outcome 3 Diarrhoea on day 5. . . . . . . . Analysis 1.4. Comparison 1 Zinc vs placebo foracute diarrhoea, Outcome 4 Diarrhoea on day 7. . . . . . . . Analysis 1.5. Comparison 1 Zinc vs placebo for acute diarrhoea, Outcome 5 Stool frequency (stools /day). . . . . Analysis 1.6. Comparison 1 Zinc vs placebo for acute diarrhoea, Outcome 6 Adverse events (vomiting). . . . . . Analysis 2.1. Comparison 2 Zinc vs placebo for mean acute diarrhoea duration: subgroup analysis excluding children < 6months, Outcome 1 Diarrhoea duration (h). . . . . . . . . . . . . . . . . . . . . . . . Analysis 3.1. Comparison 3 Zinc vs placebo for acute diarrhoea on day 7: subgroup analysis excluding children < 6 months, Outcome 1 Diarrhoea on day 7. . . . . . . . . . . . . . . . . . . . . . . . . . . . Analysis 4.1. Comparison 4 Zinc vs placebo for persistent diarrhoea, Outcome 1 Diarrhoea duration (h). . .. . Analysis 4.2. Comparison 4 Zinc vs placebo for persistent diarrhoea, Outcome 2 Diarrhoea on day 3. . . . . . . Analysis 4.3. Comparison 4 Zinc vs placebo for persistent diarrhoea, Outcome 3 Diarrhoea on day 5. . . . . . . Analysis 4.4. Comparison 4 Zinc vs placebo for persistent diarrhoea, Outcome 4 Diarrhoea on day 7. . . . . . . Analysis 4.5. Comparison 4 Zinc vs placebo for persistentdiarrhoea, Outcome 5 Stool frequency (stools/day). . . . Analysis 4.6. Comparison 4 Zinc vs placebo for persistent diarrhoea, Outcome 6 Adverse events (vomiting). . . . HISTORY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CONTRIBUTIONS OF AUTHORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DECLARATIONS OF INTEREST . . . . . . . . . . . . . . . . . . . ....