Farmaceutico

DEAN’S HANDBOOK
OF ORGANIC
CHEMISTRY
George W. Gokel, Ph.D.
Director, Program in Chemical Biology
Professor, Department of Molecular Biology and Pharmacology
Washington University School of Medicine
Professor, Department of Chemistry
Washington University
St. Louis Missouri

Second Edition

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PREFACE

The first edition of the Handbook of OrganicChemistry was edited by Professor John A.
Dean. It appeared in 1987 and has served as a widely used and convenient reference work
for more than 15 years. When Professor Dean asked if I would work with him to develop
a second edition, I was pleased to do so. I felt that as valuable as the first edition was, it
would be more broadly useful if it contained discussions of the data, the means by whichthe data were acquired, and perhaps even how the data are applied in modern science. We
thus began the revision with enhanced usability as the foremost goal. Sadly, just as we were
beginning the effort, Professor Dean passed away. He will be sorely missed.
In following the original plan, many figures, structures, discussions of the methods, and
illustrations of the data have been incorporated.Some tables have been reorganized. In
some cases tables have been printed twice; although they contain the same data, they are
arranged by different criteria. The intent is to make the data easier for the researcher to
access and use. Some Internet addresses that can serve as a supplementary resource are
included. Despite the numerous additions, the volume remains compact and accessible.
AsProfessor Dean was not involved in producing this edition, I take responsibility
for errors of fact or omission. I hope the volume is error-free, but I would appreciate
being informed of any mistakes that are found. Finally, I wish to express my thanks to
Mrs. Jolanta Pajewska, who helped in improving the manuscript and the proofreading.
GEORGE W. GOKEL

iv

ABOUT THE AUTHOR

George...