Human paipillomavirus

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Papillomavirus particles are approximately 55nm in diameter.
The capsid is composed of 72 morphological units, or capsomers, arranged on the surface of a T=7 icosahedron. Thecapsomers located at each of the 12 vertices, are pentavalent (i.e. each is surrounded by five adjacent capsomers), and the other 60 capsomers are hexavalent (each adjacent to six capsomers).
✓Manifestations include
✓ common warts (verrucae vulgaris)
✓ palmo-plantar warts, flat warts (verrucae plana)
✓ oral warts,
✓ focal epithelia hyperplasia,
✓ epidermodysplasiaverruciformis (EDV),
✓ genital warts (condyloma acuminata),
✓ Bowen papulosis, Bowen disease,
✓ papillomas of the mucosal surfaces,
✓ intraepithelial neoplasias.
Table 1.Association of HPV Types with Morphology and Site of Skin Lesions
|Lesion |Location |HPV Genotype |
|Common wart|Mostly hands |2, 4 |
|Plantar wart |Bottom of feet |1 |
|Mosaic wart|Hands and feet |2 |
|Flat wart |Arms, face, knees |3, 10, 28, 41|
|Butcher wart |Hand |7 |
|Extragenital Bowen disease |Upper and lower |2, 3, 5, 16,18, 20, 31, 33, 34, |
| |extremities, head |54, 56, 58, 61, 62, 73 |
|Macular plaques of epidermodysplasia |Light-exposed areas|5, 8, 9, 12, 14, 15, 17, 19, 20, |
|verruciformis | |21, 22, 23, 24, 25, 36, 47, 50 |

Table 2. HPV Types Associated with Anogenital...