Proceso de tablet coating

Company’s Background Information

EBSEOS GmbH is a modern worldwide trade and services company specializing in the new and used machinery mainly for the pharmaceutical and chemical industry. Their team consists of skilled personnel with solid experience in the industry technologies and international trade.
The principles of the company are:
 Good quality for a good price
 Professionalconsultation and services to their customers
 Competent customer support for product problems
 Guaranteed product insurance to our customers
EBSEOS GmbH is situated in Wehr (Germany) next to the region of Basel (Switzerland), in the area of many renowned pharmaceutical companies. Convenient location and established relations with the companies provide great potential for us and for our customersin the market of used machinery.
In their showroom you can see the new machines in action. They can also offer a possibility to perform production tests with your material.
Upon independent request their specialists can assemble purchased machinery on your premises. They also provide training for your technical staff at the company in Wehr.

HLC Series

All product touching parts are madeout of SS 316L steel. Others are out of SS 304. The loading capacity of the HLC series range from 0,4 to 650 kg. The machines are conforming to GMP standards and CE certificated.

 
Why is Tablet Coating important?

Many tablets today are coated after being pressed. Although sugar-coating was popular in the past, the process has many drawbacks. Modern tablet coatings are polymer andpolysaccharide based, with plasticizers and pigments included. Tablet coatings must be stable and strong enough to survive the handling of the tablet, must not make tablets stick together during the coating process, and must follow the fine contours of embossed characters or logos on tablets. Coatings can also facilitate printing on tablets, if required. Coatings are necessary for tablets that have anunpleasant taste, and a smoother finish makes large tablets easier to swallow. Tablet coatings are also useful to extend the shelf-life of components that are sensitive to moisture or oxidation. Special coatings can enhance brand recognition.
If the active ingredient of a tablet is sensitive to acid, or is irritant to the stomach lining, an enteric coating can be used, which is resistant to stomachacid and dissolves in the high pH of the intestines. Enteric coatings are also used for medicines that can be negatively affected by taking a long time to reach the small intestine where they are absorbed. Coatings are often chosen to control the rate of dissolution of the drug in the gastro-intestinal tract. Some drugs will be absorbed better at different points in the digestive system. If thehighest percentage of absorption of a drug takes place in the stomach, a coating that dissolves quickly and easily in acid will be selected. If the rate of absorption is best in the large intestine or colon, then a coating that is acid resistant and dissolves slowly would be used to ensure it reached that point before dispersing. The area of the gastro-intestinal tract with the best absorption for anyparticular drug is usually determined by clinical trials.
This is the last stage in tablet formulation and it is done to protect the tablet from temperature and humidity constraints. It is also done to mask the taste, give it special characteristics, distinction to the product, and prevent inadvertent contact with the drug substance. The most common forms of tablet coating are sugar coating andfilm coating.
Coating is also performed for the following reasons:
 Controlling site of drug release
 Providing controlled, continuous release or reduce the frequency of drug dosing
 Maintaining physical or chemical drug integrity
 Enhancing product acceptance and appearance
Sugar coating is done by rolling the tablets in heavy syrup, in a similar process to candy making. It is done to...