Farmacologia

1.
Ann Pharmacother. 2010 Mar;44(3):489-506. doi: 10.1345/aph.1M332. Epub 2010 Feb 11.
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitativereview.
Pierce CA, Voss B.
Critical Care Specialty Residency Department of Pharmacy, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA. capierce@wfubmc.edu
AbstractOBJECTIVE:
To evaluate the analgesic and antipyretic efficacy and safety of ibuprofen compared to acetaminophen in children and adults.
DATA SOURCES:
Literature searches were performed usingPubMed/MEDLINE (through August 2009) and EMBASE (through January 2008) and were restricted to the English language. In PubMed/MEDLINE, search terms used were ibuprofen, acetaminophen, paracetamol, clinicaltrials, and randomized controlled trials. EMBASE search terms included ibuprofen and acetaminophen, restricted to human and clinical trials.
STUDY SELECTION AND DATA EXTRACTION:
All English-languagearticles identified from the data sources were reviewed. Multiple review articles were studied for any pertinent references and this yielded additional articles. Only articles that directly comparedibuprofen and acetaminophen were eligible for this review.
DATA SYNTHESIS:
Eighty-five studies that directly compared ibuprofen to acetaminophen were identified; 54 contained analgesic efficacy data,35 contained antipyretic/temperature reduction data, and 66 contained safety data (some articles contained more than 1 type of data). Qualitative review of the literature revealed that, for the mostpart, ibuprofen was more efficacious than acetaminophen for the treatment of pain and fever in both pediatric and adult populations, and that these 2 drugs were equally safe. Meta-analyses on thesubset of randomized clinical trial articles that reported sufficient quantitative information to calculate either an odds ratio (adverse event [AE]) or standardized mean difference (pain and fever)...