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Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells
Am J Physiol Renal Physiol 298:F1244-F1253, 2010. First published 16 December 2009; doi:10.1152/ajprenal.00662.2009 You might find this additional info useful... Supplemental material for this article can be found at: This article cites 26 articles, 13 of which can be accessed free at:

Gary E. Olson, John C. Whitin, Kristina E. Hill, Virginia P. Winfrey, Amy K. Motley, Lori M. Austin, Jacqualyn Deal, Harvey J. Cohen and Raymond F. Burk

Thisarticle has been cited by 2 other HighWire hosted articles Glutathione peroxidase-3 produced by the kidney binds to a population of basement membranes in the gastrointestinal tract and in other tissues Raymond F. Burk, Gary E. Olson, Virginia P. Winfrey, Kristina E. Hill and Dengping Yin Am J Physiol Gastrointest Liver Physiol, July , 2011; 301 (1): G32-G38. [Abstract] [Full Text] [PDF] Adaptivedysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging Joyce C. McCann and Bruce N. Ames FASEB J, June , 2011; 25 (6): 1793-1814. [Abstract] [Full Text] [PDF] Updated information and services including high resolution figures, can be found at: material and information about AJP - Renal Physiology can be found at:

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AJP - Renal Physiology publishes original manuscripts on a broad range of subjects relating to the kidney, urinary tract, and their respective cells andvasculature, as well as to the control of body fluid volume and composition. It is published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 2010 by the American Physiological Society. ISSN: 0363-6127, ESSN: 1522-1466. Visit our website at

Am J Physiol Renal Physiol 298: F1244–F1253, 2010. Firstpublished December 16, 2009; doi:10.1152/ajprenal.00662.2009.

Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells
Gary E. Olson,1* John C. Whitin,2* Kristina E. Hill,3 Virginia P. Winfrey,1 Amy K. Motley,3 Lori M. Austin,3 Jacqualyn Deal,3 Harvey J. Cohen,2 and Raymond F. Burk3
Department of Cell and Developmental Biology and3Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, and 2Department of Pediatrics, Stanford University School of Medicine, Stanford, California
Submitted 18 November 2009; accepted in final form 11 December 2009

Olson GE, Whitin JC, Hill KE, Winfrey VP, Motley AK, Austin LM, Deal J, Cohen HJ, Burk RF.Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells. Am J Physiol Renal Physiol 298: F1244 –F1253, 2010. First published December 16, 2009; doi:10.1152/ajprenal.00662.2009.—Glutathione peroxidase-3 (Gpx3), also known as plasma or extracellular glutathione peroxidase, is a selenoprotein secreted primarily by kidney proximalconvoluted tubule cells. In this study Gpx3 / mice have been produced and immunocytochemical techniques have been developed to investigate Gpx3 metabolism. Gpx3 / mice maintained the same whole-body content and urinary excretion of selenium as did Gpx3 / mice. They tolerated selenium deficiency without observable ill effects. The simultaneous knockout of Gpx3 and selenoprotein P revealed that these two...
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