Malaria
Five species of malaria can infect and be transmitted by humans. Severe disease is largely caused by Plasmodium falciparum while the disease caused byPlasmodium vivax, Plasmodium ovale,[1] and Plasmodium malariae is generally a milder disease that is rarely fatal. Plasmodium knowlesi is a zoonosis that causes malaria in macaques but can also infecthumans.[2][3]
Malaria transmission can be reduced by preventing mosquito bites by distribution of mosquito nets and insect repellents, or by mosquito-control measures such as spraying insecticides anddraining standing water (where mosquitoes breed). Despite a clear need, no vaccine offering a high level of protection currently exists. Efforts to develop one are ongoing.[4] A number of medicationsare also available to prevent malaria in travelers to malaria-endemic countries (prophylaxis).
A variety of antimalarial medications are available. Severe malaria is treated with intravenous orintramuscular quinine or, since the mid-2000s, the artemisinin derivative artesunate,[5] which is superior to quinine in both children and adults.[6] Resistance has developed to several antimalarial drugs,most notably chloroquine.[7]
There were an estimated 225 million cases of malaria worldwide in 2009.[8] An estimated 655,000 people died from malaria in 2010,[9] a decrease from the 781,000 who diedin 2009 according to the World Health Organization's 2011 World Malaria Report, accounting for 2.23% of deaths worldwide.[8] However, a 2012 meta-study from the University of Washington and...
Regístrate para leer el documento completo.