Neuromuscular Function And Acetylcholin-Esterase In The Pectoral Abductor Muscle Of Large-Mouth Bass

Neuromuscular Function and Acetylcholin-Esterase in the Pectoral Abductor Muscle of Large-Mouth Bass (Micropterus Salmoides) as Evidenced by the Effects of Diisopropylfluorophosphate
Schneider,PWJr | Weber, LJ
Journal of the Fisheries Research Board of Canada Vol. 32, p. 2153-2161, 1975, 1 tab, 4 fig, 27 ref.

The significance of acetylcholinesterase (AChE) to neuromuscular transmission inthe pectoral fin abductor muscle of largemouth bass (Micropterus salmoides) was evaluated by establishing in vivo, first, the occurrence of enzyme inhibition by diisopropylfluorophosphate (DFP) and,second, the correlation between muscular response to indirect stimulation and enzyme inhibition. Dose response curves for inhibition of AChE by DFP indicated that DFP had access to and did inhibitAChE. Modification of the muscular response was observed and severity appeared to be positively correlated to AChE inhibition. The modification, however, was not typical of cholinergic systems in thatthe ability to produce and maintain a tetanus was never abolished even with inhibition in excess of 99% of control levels. It was concluded that AChE is not as important for neuromuscular transmissionin largemouth bass as has been established for other vertebrates, and that the acute toxic effects of DFP to largemouth bass are not mediated by a collapse of neuroskeletal muscle function. (Katz)http://md1.csa.com/partners/viewrecord.php?requester=gs&collection=ENV&recid=7703028&q=cholinesterase+in+micropterus+salmoides&uid=790521425&setcookie=yes

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Hiran M. Dutta, and Dane A. Arends
Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
Received 4 April 2002; 
revised 3 October 2002; 
accepted 4 November...