ARTICULO ANATOMIA
Páginas: 3 (562 palabras)
Publicado: 5 de abril de 2015
The impact of oxaliplatin-based chemotherapy for colorectal cancer on the autonomous nervous system
Background
The oxaliplatin (ΟΧΑ)-based regimens FOLFOX and XELOX can cause peripheral neuropathy.It is unknown if ΟΧΑ, alone or in combination regimens, affects the Autonomous Nervous System (ANS). Accordingly, we evaluated the impact of ΟΧΑ-based chemotherapy on the ANS.
Methods
We enrolled 36patients with colorectal cancer, treated with adjuvant mFOLFOX6 or XELOX chemotherapy, and 22 healthy volunteers. For the assessment of ANS function, participants completed a questionnaire andunderwent neurophysiological examination at three time points (baseline, 3–4 months and 6–8 months after the first chemotherapy cycle). ANS testing included assessment of the adrenergic cardiovascularfunction (orthostatic hypotension-OH), parasympathetic heart innervation (ratio 30/15) and Sympathetic Skin Response (SSR).
Results
The values of the 30/15 ratio were significantly reduced at the two timepoint assessments compared to baseline (Wilcoxon signed ranks test, both P < 0.001), while patients had more often diastolic OH at the 6–8 month evaluation compared to baseline (P = 0.039). In contrast,SSR was not affected. The incidence of positive responses in the questionnaire assessing the subjective impact of symptoms attributable to ANS dysfunction was higher at the two time points comparedto baseline (P = 0.036 and P = 0.020).
Conclusions
Oxaliplatin-based chemotherapy is associated with significant effects on the adrenergic cardiovascular reaction and the parasympathetic heartinnervation, whereas SSR remains untouched.
1. E. V. Dermitzakis1,*,
2. V. K. Kimiskidis2,
3. A. Eleftheraki3,
4. G. Lazaridis4,
5. A. Konstantis4,
6. G. Basdanis5,
7. I. Tsiptsios1,
8. G.Georgiadis6 and
9. G. Fountzilas4
Article first published online: 17 JUL 2014
DOI: 10.1111/ene.12514
TRADUCCIÓN
El impacto de la quimioterapia basada en oxaliplatino para el cáncer colorrectal en el sistema...
Background
The oxaliplatin (ΟΧΑ)-based regimens FOLFOX and XELOX can cause peripheral neuropathy.It is unknown if ΟΧΑ, alone or in combination regimens, affects the Autonomous Nervous System (ANS). Accordingly, we evaluated the impact of ΟΧΑ-based chemotherapy on the ANS.
Methods
We enrolled 36patients with colorectal cancer, treated with adjuvant mFOLFOX6 or XELOX chemotherapy, and 22 healthy volunteers. For the assessment of ANS function, participants completed a questionnaire andunderwent neurophysiological examination at three time points (baseline, 3–4 months and 6–8 months after the first chemotherapy cycle). ANS testing included assessment of the adrenergic cardiovascularfunction (orthostatic hypotension-OH), parasympathetic heart innervation (ratio 30/15) and Sympathetic Skin Response (SSR).
Results
The values of the 30/15 ratio were significantly reduced at the two timepoint assessments compared to baseline (Wilcoxon signed ranks test, both P < 0.001), while patients had more often diastolic OH at the 6–8 month evaluation compared to baseline (P = 0.039). In contrast,SSR was not affected. The incidence of positive responses in the questionnaire assessing the subjective impact of symptoms attributable to ANS dysfunction was higher at the two time points comparedto baseline (P = 0.036 and P = 0.020).
Conclusions
Oxaliplatin-based chemotherapy is associated with significant effects on the adrenergic cardiovascular reaction and the parasympathetic heartinnervation, whereas SSR remains untouched.
1. E. V. Dermitzakis1,*,
2. V. K. Kimiskidis2,
3. A. Eleftheraki3,
4. G. Lazaridis4,
5. A. Konstantis4,
6. G. Basdanis5,
7. I. Tsiptsios1,
8. G.Georgiadis6 and
9. G. Fountzilas4
Article first published online: 17 JUL 2014
DOI: 10.1111/ene.12514
TRADUCCIÓN
El impacto de la quimioterapia basada en oxaliplatino para el cáncer colorrectal en el sistema...
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